Genes, Vol. 12, Pages 1482: Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

Genes, Vol. 12, Pages 1482: Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings Genes doi: 10.3390/genes12101482 Authors: Line K. M. Lybech Marco Calabró Silvana Briuglia Antonio Drago Concetta Crisafulli Suicide in Bipolar Disorder (BD) is a relevant clinical concern. Genetics may shape the individual risk for suicide behavior in BD, together with known clinical factors. The lack of consistent replication in BD may be associated with its multigenetic component. In the present contribution we analyzed a sample of BD individuals (from STEP-BD database) to identify the genetic variants potentially associated with three different suicide-related phenotypes: 1) a feeling that the life was not worth living; 2) fantasies about committing a violent suicide; 3) previous attempted suicide. The sample under analysis included 1115 BD individuals. None of the SNPs reached genome-wide significance. However, a trend of association was evidenced for rs2767403, an intron variant of AOPEP gene, in association with phenotype #1 (p = 5.977 × 10−6). The molecular pathway analysis showed a significant enrichment in all the investigated phenotypes on pathways related to post synaptic signaling, neurotransmission and neurodevelopment. Further, NOTCH signaling or the γ-aminobutyric acid (GABA) -ergic signaling were found to be associated with specific suicide-related phenotypes. The present investigation contributes to the hypothesis that the genetic architectu...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research