Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations

This study indicates that diazepam caused a decline in cognitive function depending on hippocampal activity. Telmisartan, a common antihypertensive agent and metformin, a traditional antidiabetic drug improved this cognitive dysfunction through their anti-oxidant and anti-inflammatory effect as they decreased initial and retention transfer latency as well as it increased step down latency. Also they decreased TNF-α, NFκB, and Caspase 3 and upregulated AMPK expression, moreover they ameliorated the hippocampal morphological alterations, GFAP and COX-2 immunoexpression.PMID:34547248 | DOI:10.1016/j.ejphar.2021.174511

Source: European Journal of Pharmacology - September 21, 2021 Category: Drugs & Pharmacology Authors: Eman S Said Asmaa M Elsayed Laila A Rashed Eman H Nadwa Njood A Alsuhaibani Batool S Alfuraih Rania H Mahmoud Source Type: research