IL13Ralpha2 promotes proliferation and outgrowth of breast cancer brain metastases

CONCLUSIONS: Non-genomic phenotypic adaptations at metastatic sites are critical to BM progression and patients' prognosis. This study opens the road to use IL13Rα2-targeting as a therapeutic strategy for BM.PMID:34544797 | DOI:10.1158/1078-0432.CCR-21-0361

Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: R Alejandro Marquez-Ortiz Maria J Contreras-Zarate Vesna Tesic Karen Lf Alvarez-Eraso Gina Kwak Zachary Littrell James C Costello Varsha Sreekanth D Ryan Ormond Sana D Karam Peter Kabos Diana M Cittelly Source Type: research