A bifunctional squaramide-catalysed enantioselective vinylogous Michael addition/cyclization cascade reaction of 4-unsaturated isoxazol-5-ones and α,α-dicyanoalkenes

Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01256H, PaperYu Wang, Cheng Niu, Dong-Hua Xie, Da-Ming Du An effective strategy for the stereoselective synthesis of spiro isoxazolone-cyclohexenimines was developedvia a squaramide-catalysed vinylogous Michael addition/cyclization cascade reaction of 4-unsaturated isoxazol-5-ones and α,α-dicyanoalkenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research