Methodical considerations on adjusting for Charlson Comorbidity Index in epidemiological studies

In conclusion, the choice of CCI adjustment strategy impacts mitigation of bias in this simulation study, and suboptimal adjustment strategies can cause an observable bias, althoug h of quite limited magnitude of only a few percent in this simulation example. Researcher should be careful when deciding on the adjustment strategies applied to ensure that the desired mitigation of bias sources is achieved.

Source: European Journal of Epidemiology - September 4, 2021 Category: Epidemiology Source Type: research