Genetic and epigenetic coordination of cortical interneuron development

Nature, Published online: 22 September 2021; doi:10.1038/s41586-021-03933-1The transcriptional programs and chromatin accessibility changes that cause two related interneuronal subtypes to diverge from common developmental origins and acquire specialized properties are elucidated.
Source: Nature AOP - Category: Research Authors: Source Type: research

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ConclusionResults show absence of effectiveness in the systematic use of metoclopramide as prophylaxis of GERD symptoms in premature infants. Additionally, no adverse effects attributable to the drug were NCT02907632; September 20, 2016. Retrospectively registered.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
Conclusion: The esophageal motility disorders co-occurring with endoscopic and histological anomalies do not significantly affect the severity of dysphagia, however, in the case of patients with ERD and SR and concomitant UES insufficiency, this motor dysfunction has a significant impact on the reduction in the patients’ quality of life. Although no specific esophageal motility pattern typical of EoE, ERD and SR has been identified, comparative assessment of manometric features may have a potential role in differential diagnosis.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
To analyze pre to posttreatment voice changes regarding the type of reflux in patients with acid, weakly acid or alkaline laryngopharyngeal reflux (LPR).
Source: Journal of Voice - Category: ENT & OMF Authors: Source Type: research
Esophageal sphincter augmentation (ESA) has been shown to significantly improve gastroesophageal reflux disease (GERD) symptoms in patients with moderate-severe GERD. The indication for ESA currently excludes patients with moderate-severe GERD with prior bariatric surgery or partial gastrectomy.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Bariatric and Foregut Source Type: research
Roux-en-Y gastric bypass (RYGBP) is the preferred procedure for morbidly obese patients with gastroesophageal reflux disease (GERD). Vertical sleeve gastrectomy (VSG) may worsen GERD postoperatively. We assessed the diagnostic yield and clinical impact of routine comprehensive preoperative evaluation.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Bariatric and Foregut Source Type: research
CONCLUSION: Our study describes the process of conceptualization, design and production of a practical, safe, low-cost continuous supraglottic suction device without representing antibiotic pressure, which appears to be a new complementary preventive strategy for the standard management of intubated and mechanically ventilated patients.PMID:34675695 | PMC:PMC8502029 | DOI:10.2147/MDER.S328485
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS: Most patients who underwent EGD for refractory GERD symptoms alone did not have pathological findings requiring a change in management. Screening EGD for patients only with persistent reflux symptoms should not be routinely recommended.PMID:34669534 | DOI:10.1080/00365521.2021.1988141
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
ConclusionsFew complementary examinations are systematically needed and their performance is increased if they are oriented by a careful history and physical examination which then allows to advance in the diagnostic procedure.Key messagesComplementary examinations are largely inconclusive and only a history and complete clinical examination can make it possible to advance in the diagnostic procedure.Infants who demonstrate historical or physical examination elements suggestive of a specific etiology of their event, such as gastroesophageal reflux, should be evaluated and treated accordingly.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsOver the study period, there was an increase in the incidence of oesophageal cancer in England. The largest increase was seen in rates of adenocarcinoma. Considering obesity has a strong temporal association with oesophageal adenocarcinoma, further research is needed to understand the biological mechanisms of this association to inform public health efforts to reduce the prevalence of obesity.Key messagesFurther research and analysis of routinely collected data on histological subtypes of oesophageal cancer can provide insight into the increasing trend in incidence.Considering the strong association between obes...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
CONCLUSIONS: Standardizing the gastric sleeve technique in the bariatric surgery services, taking into account the technical factors associated with post-operative GERD de novo, decreases its appearance as evaluated by the GerdQ scale.PMID:34665173 | DOI:10.24875/CIRU.20000642
Source: Cirugia y Cirujanos - Category: Surgery Authors: Source Type: research
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