Benefits of α-lipoic acid in high-risk pregnancies (Review)

Exp Ther Med. 2021 Nov;22(5):1232. doi: 10.3892/etm.2021.10666. Epub 2021 Aug 31.ABSTRACTα-Lipoic acid (ALA) is a natural molecule that is inconsistently synthesized by the human body and must be provided from exogenous sources, such as food and dietary supplements. Once absorbed, the oxidized form of ALA is transformed into its reduced form, dihydrolipoic acid (DHLA). ALA/DHLA exert direct and indirect antioxidant, anti-inflammatory and fine immunomodulatory effects. ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10). They also inhibit cyclooxygenase 2, thereby decreasing the secretion of prostaglandin E2 and nitrogen oxide, and reducing the risk of miscarriage in the first trimester of pregnancy. In patients at risk of abortion, administration of ALA from the first trimester has shown efficacy by accelerating subchorionic hematoma resorption, with a significant decrease in the accompanying abdominal pain. ALA has been proven to be efficient in maintaining the length of the cervix and keeping it closed following one episode of premature labor. Preeclampsia is a dysfunction caused by abnormal placentation and an excessive maternal inflammatory response, leading to extreme hypoxia in the placental bed and exaggerated oxidative stress, with release of oxygen free radicals. Oxidative stress plays a key role in the development of preeclampsia and intrauterine grow...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research

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We report a case of 32-year-old woman, gravida 6 para 3 with a history of two previous miscarriages. She presented with a pelvic pain to our emergency department. She was hemodynamically stable with a beta human chorionic gonadotropin serum level of 26342 IU/L. Ultrasound was suspicious for an interstitial pregnancy (Figure 1). After patient consent, surgical management was decided considering her obstetrical history. She underwent an explorative laparoscopy; a non-ruptured left cornual pregnancy was found (Figure 2).
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
CONCLUSIONS: No studies reported on our primary outcome of live birth rate. Due to the very limited evidence, we are uncertain of the effects of pentoxifylline on clinical pregnancy rate, miscarriage rate, or overall pain. There is currently insufficient evidence to support the use of pentoxifylline in the management of women with endometriosis with respect to subfertility and pain relief outcomes.PMID:34431079 | DOI:10.1002/14651858.CD007677.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
AbstractStudy questionDoes Buscopan ® reduce abdominal pain experienced by women undergoing ultrasound-guided manual vacuum aspiration (USG-MVA)?Summary answerThe addition of 20mg Buscopan ® intravenous injection was not associated with a statistical reduction in pain score but leads to a higher patient satisfaction score.What is known alreadyUltrasound-guided Manual Vacuum aspiration is a feasible and effective out-patient treatment option for treating early pregnancy loss. However, it is associated with a moderate amount of pain due to uterine contraction.Study design, size, durationThis randomised, double-blinde...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionDoes Buscopan ® reduce abdominal pain experienced by women undergoing ultrasound-guided manual vacuum aspiration (USG-MVA)?Summary answerThe addition of 20mg Buscopan ® intravenous injection was not associated with a statistical reduction in pain score but leads to a higher patient satisfaction score.What is known alreadyUltrasound-guided Manual Vacuum aspiration is a feasible and effective out-patient treatment option for treating early pregnancy loss. However, it is associated with a moderate amount of pain due to uterine contraction.Study design, size, durationThis randomised, double-blinde...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionHas the COVID –19 pandemic and public health guidance impacted referrals, outcome and management of early pregnancy in the emergency room?Summary answerCOVID –19 changed the way in which women sought guidance and accessed services in early pregnancy.What is known alreadySpontaneous miscarriage is the most common complication of pregnancy1. Experiencing an early pregnancy loss is often an unexpected and difficult time that can be physically traumatising2. A previous study looking at the experience of a miscarriage from both the female and male point of view identified that long waiting time...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionHow to assess the different adenomyosis phenotype before and after pregnancy on magnetic resonance imaging according to stringent validated criteria ?Summary answerDiffuse adenomyosis increases significantly after pregnancy while the rate of focal adenomyosis and the mean volume of focal adenomyosis lesions decrease significantly after pregnancy.What is known alreadyAdenomyosis and endometriosis are benign hormone-dependent disorders associated with pelvic pain, dysmenorrhea and/or infertility. The natural course of adenomyosis and endometriosis is still unclear, particularly during pregnancy. Pregnan...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionTo assess the effect of pentoxifylline, a methyl-xanthine with anti-inflammatory effects, for the management of premenopausal women with endometriosis.Summary answerThere is not enough evidence to support the use of pentoxifylline in the management of premenopausal women with endometriosis to improve fertility and pain outcomes.What is known alreadyEndometriosis is a chronic, inflammatory condition that occurs mainly during the reproductive years. It is characterized by endometrium-like tissue developing outside the uterine cavity. This endometriotic tissue development is dependent on estrogen produce...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
This study identifies a metabolite profile associated with VIUPs. These findings may be useful in the development of a diagnostic test to confirm VIUPs and thus exclude potentially life-threatening pregnancy outcomes. Such a test would be invaluable in clinical emergencies.Trial registration numberNA
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
This study is a retrospective, non-interventional monocentric cohort study conducted between January 2011 and December 2017 in Institut de Medecine de la Reproduction - Clinique Bouchard in Marseilles, France.Participants/materials, setting, methodsThe outcome of pregnancies obtained after IVF and/or ICSI in patients with endometriosis (n  = 270) was compared with patients,free of endometriosis,monitored for male infertility (n = 366) The statistical study was carried out using GraphPad Version 8 The Student T-test was used to compare means across them. Results were considered significant for p&...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionWhat are the risk factors for early pregnancy loss (EPL) after in vitro fertilization-embryo transfer (IVF-ET)?Summary answerThe maternal age, gestational sac diameter, embryonic length, yolk sac diameter, heart rate of day 27 –29 and endometrium thickness on transfer day were risk factors. What is known already: The first routine ultrasound scan is commonly arranged on day 27–29 after IVF-ET in most reproductive centers in China to determine the location and viability of the embryo. Individual maternal factors, such as a high maternal age (MA) and abnormal ultrasound parameters such as em...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
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