POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium

In this study, we show that performing a prior dimensionality reduction on FOM snapshots through randomized proper orthogonal decomposition (POD) enables to speed up training times and to decrease networks complexity. Accuracy and efficiency of this strategy, which we refer to as POD-DL-ROM, are assessed in the context of cardiac EP on an idealized left atrium (LA) geometry and considering snapshots arising from a NURBS (non-uniform rational B-splines)-based isogeometric analysis (IGA) discretization. Once the ROMs have been trained, POD-DL-ROMs can efficiently solve both physiological and pathological cardiac EP problems, for any new scenario, in real-time, even in extremely challenging contexts such as those featuring circuit re-entries, that are among the factors triggering cardiac arrhythmias.
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Mol Med Rep. 2021 Dec;24(6):870. doi: 10.3892/mmr.2021.12510. Epub 2021 Oct 26.ABSTRACTAtrial fibrillation (AF) is one of the most common forms of cardiac arrhythmia. Novel evidence has indicated that a competing endogenous RNA (ceRNA) mechanism may occur in AF. The present study aimed to identify differentially expressed microRNAs (miRNAs/miRs) in AF and predict their targeting long non‑coding RNAs (lncRNAs) to identify a potential ceRNA network involved in AF using bioinformatics analysis. The GSE68475 microarray dataset was downloaded from the Gene Expression Omnibus database and differentially expressed miRNAs in AF ...
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research
Hamostaseologie. 2021 Oct;41(5):372-378. doi: 10.1055/a-1581-6881. Epub 2021 Oct 25.ABSTRACTSince the coronavirus disease (COVID-19) pandemic spread unrelentingly all over the world, millions of cases have been reported. Despite a high number of asymptomatic cases, the course of the disease can be serious or even fatal. The affection of the myocardium, called myocardial injury, is caused by multiple triggers. The occurrence of cardiac arrhythmias in COVID-19 patients with myocardial involvement and a critical course is common. In this review, potential mechanisms, incidence, and treatment options for cardiac arrhythmias in...
Source: Hamostaseologie - Category: Hematology Authors: Source Type: research
Discussion Anorexia nervosa is an eating disorder with an intense fear of being overweight (i.e. distorted body image), and self-starvation and excessive weight loss. It is more common in women (1.2%) than men (0.2%) but can be seen in both genders. Risk factors include high-intelligence, perfectionism/inflexibility, anxiety, activities where thinner body types are expected (e.g. dancer, diver, gymnast, long-distance runner, volleyball player, etc.) Other eating disorders include bulimia nervosa (i.e. cycles of binge eating and then purging), binge eating disorder (i.e. purging), orthorexia (i.e. obsessions with healthful ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Many types of cardiac arrhythmias can occur in people with COVID-19, and these arrhythmias can affect the patient's outcomes. We have experienced paroxysmal complete atrioventricular block in a patient with COVID-19 and would like to share the course of treatment. AbstractMany types of cardiac arrhythmias can occur in people with COVID-19, and these arrhythmias can affect the patient's outcomes. We have experienced paroxysmal complete atrioventricular block in a patient with COVID-19 and would like to share the course of treatment.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
CONCLUSIONS: We are certain that risk of death in hospitalised COVID-19 patients is not reduced by treatment with azithromycin after 28 days. Further, based on moderate-certainty evidence, patients in the inpatient setting with moderate and severe disease probably do not benefit from azithromycin used as potential antiviral and anti-inflammatory treatment for COVID-19 regarding clinical worsening or improvement. For the outpatient setting, there is currently low-certainty evidence that azithromycin may have no beneficial effect for COVID-19 individuals. There is no evidence from RCTs available for other antibiotics as anti...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
Cryptogenic stroke is defined as a stroke without definitive etiology, not attributed to cerebral atherosclerotic disease, cardiac arrhythmia or structural cardiac abnormalities. Patent foramen ovale (PFO) has been shown to be a route by which paradoxical embolus can cause strokes. While PFO is found in approximately 25% of the general population, PFOs are significantly mo...
Source: Radcliffe Cardiology - Category: Cardiology Authors: Source Type: research
ConclusionsTo reduce the risk of cardiac arrhythmias and to improve patient outcomes, consideration of accurate patient selection, concomitant medications, electrolyte monitoring, and vigilant ECG monitoring should be considered.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
Tex Heart Inst J. 2021 Sep 1;48(4):e217548. doi: 10.14503/THIJ-21-7548.NO ABSTRACTPMID:34669954 | DOI:10.14503/THIJ-21-7548
Source: Texas Heart Institute Journal - Category: Cardiology Authors: Source Type: research
Tex Heart Inst J. 2021 Sep 1;48(4):e217646. doi: 10.14503/THIJ-21-7646.NO ABSTRACTPMID:34669952 | DOI:10.14503/THIJ-21-7646
Source: Texas Heart Institute Journal - Category: Cardiology Source Type: research
Tex Heart Inst J. 2021 Sep 1;48(4):e217548. doi: 10.14503/THIJ-21-7548.NO ABSTRACTPMID:34669954 | DOI:10.14503/THIJ-21-7548
Source: Texas Heart Institute Journal - Category: Cardiology Authors: Source Type: research
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