A Phase II Cluster-Crossover Randomized Trial of Fentanyl vs. Morphine for Analgosedation in Mechanically Ventilated Patients

CONCLUSIONS: Among adult patients requiring mechanical ventilation, compared with morphine, fentanyl infusion significantly increased the median number of ventilator free days at day 28. The choice of opioid infusion agent may affect clinical outcomes and requires further investigation. Clinical trial registration available at https://www.anzctr.org.au/, ID: ACTRN12619000939190.PMID:34543581 | DOI:10.1164/rccm.202106-1515OC

Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2021 Category: Respiratory Medicine Authors: Andrew J Casamento Ary Serpa Neto Marcus Young Mervin Lawrence Christina Taplin Glenn M Eastwood Angajendra Ghosh Rinaldo Bellomo Assessment of Opioid Administration to Lead to Analgesic Effects and Sedation in Intensive Care (ANALGESIC) trial centers Source Type: research