Cancers, Vol. 13, Pages 4734: Gene Expression Profiling as a Potential Tool for Precision Oncology in Non-Small Cell Lung Cancer

Cancers, Vol. 13, Pages 4734: Gene Expression Profiling as a Potential Tool for Precision Oncology in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers13194734 Authors: Sara Hijazo-Pechero Ania Alay Raúl Marín Noelia Vilariño Cristina Muñoz-Pinedo Alberto Villanueva David Santamaría Ernest Nadal Xavier Solé Recent technological advances and the application of high-throughput mutation and transcriptome analyses have improved our understanding of cancer diseases, including non-small cell lung cancer. For instance, genomic profiling has allowed the identification of mutational events which can be treated with specific agents. However, detection of DNA alterations does not fully recapitulate the complexity of the disease and it does not allow selection of patients that benefit from chemo- or immunotherapy. In this context, transcriptional profiling has emerged as a promising tool for patient stratification and treatment guidance. For instance, transcriptional profiling has proven to be especially useful in the context of acquired resistance to targeted therapies and patients lacking targetable genomic alterations. Moreover, the comprehensive characterization of the expression level of the different pathways and genes involved in tumor progression is likely to better predict clinical benefit from different treatments than single biomarkers such as PD-L1 or tumor mutational burden in the case of immunotherapy. However, intrinsic technical and ana...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research