Evaluation of BioPlex 2200 tTG-IgA Diagnostic Performance for Serology-Based Diagnosis of Celiac Disease

Am J Clin Pathol. 2021 Sep 20:aqab104. doi: 10.1093/ajcp/aqab104. Online ahead of print.ABSTRACTOBJECTIVES: Forgoing biopsy for the diagnosis of celiac disease in children with tissue transglutaminase immunoglobulin A (tTG-IgA) levels greater than or equal to 10 times the upper limit of normal (≥10×ULN) has been advocated by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition.METHODS: Our retrospective study tested the specificity and positive predictive value (PPV) of the BioPlex 2200 assay (Bio-Rad Laboratories) in diagnosing celiac disease at the ≥10×ULN tTG-IgA threshold, which is ≥150 U/mL (negative
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Source Type: research

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ConclusionScreening for celiac disease should be considered in patients with iron deficiency anemia of obscure origin
Source: QJM - Category: Internal Medicine Source Type: research
J Clin Res Pediatr Endocrinol. 2021 Aug 18. doi: 10.4274/jcrpe.galenos.2021.2021.0139. Online ahead of print.ABSTRACTIt is well-known that in children with type 1 diabetes (T1D), the frequency of celiac disease (CD) is increased due to unclear mechanisms including autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is gold standard, avoiding unnecessary endoscopy is crucial. Therefore, from the perspective of the clinicians and patients' families, the diagnosis of celiac disease remains challenging. With these in mind, a joint working group (Type 1 Diabetes and Celiac Disease Jo...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
We examined the yield of colonoscopy and upper endoscopy in IBS for several organic diseases.METHODS: Matched population-based prevalence study in Sweden. We identified 21,944 participants diagnosed with IBS from 1987 to 2016 undergoing colonoscopy with a biopsy from all of Sweden's 28 pathology departments within 6 months of diagnosis. We compared prevalence of histopathology-proven diagnoses of inflammatory bowel disease (IBD), colorectal cancer, precancerous polyps, and microscopic colitis between patients recently diagnosed with IBS and matched controls without IBS (n = 81,101) undergoing colonoscopy. We also compared ...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Source Type: research
A 60-year-old male presented to the emergency department with severe anemia (hemoglobin 6.3  g/dL) on routine follow-up. The patient reported no visible gastrointestinal blood loss. His past medical condition was unremarkable and was not taking any medication. Laboratory studies revealed a microcytic (VGM 61.6 fL) and hypochromic (CHGM 26.4 g/dL) anemia, with iron deficiency. The patient subsequently underwent upper endoscopy and colonoscopy, the latter one unremarkable. A diffuse nodular mucosa with scalloping was found in the second part of the duodenum on esophagogastroduodenoscopy, and biopsies revealed incre...
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
This study included 72 patients affected by CD followed-up at our center, namely 49 uncomplicated CD before and after GFD and 23 RCD. Serum levels of chromogranin A (CgA) and β2-microglobuline were measured at baseline and at follow-up (median time of 13 months) in each group of patients. Cut-off points for each marker were estimated to differentiate RCD from uncomplicated CD patients. Serum levels of CgA and β2-microglobuline were significantly higher in patients with RCD compared to uncomplicated CD (p < 0.001), both at baseline and at follow-up, with no significant difference between RCD type 1 and type...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSION: Gastric and duodenal biopsy specimens seem to have limited diagnostic value for the exclusion of generalized or eosinophilic GI disorders in adults with EoE.KEY POINTSEvidence is lacking on the diagnostic value of additional biopsies sampled form the stomach and duodenum to rule out other relevant generalized or eosinophilic gastrointestinal (GI) disorders.The yield of gastric and duodenal biopsies routinely sampled in our cohort was 3.6% for a relevant other generalized or eosinophilic GI diagnosis and 30% for other histological diagnosis such as non-specific or H. Pylori gastritis.The diagnostic yield for a r...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
ConclusionsHelicobacter pylori gastritis and celiac disease were more commonly observed in association with low ferritin levels. Low ferritin levels without anemia can be an early and silent sign of celiac disease.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
We read the clinical practice guideline “AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia” with both interest and concern.1,2 Interest because for reproductive aged women, iron deficiency (ID) and ID anemia (IDA) are highly prevalent and symptomatic disorders both domestically and worldwide , and concern because of, and despite the “lack of direct data…in premenopausal women,” bidirectional endoscopy is recommended for all. These recommendations are in stark contrast with those of the British Society of Gastroenterology published in 2011 and aimed ...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
CONCLUSION: The prevalence of SIBO was 31% in unresponsive patients with CeD according to LHBT and 15% in the quantitative culture of the jejunal aspirate, which is comparable with the published Western literature.PMID:33361039 | PMC:PMC7759221 | DOI:10.5152/tjg.2020.19627
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Discussion Helicobacter pylori (H. pylori) is a microaerophilis, spiral bacterium that is a prevalent human pathogen. How this infection affects individuals is different in adults and children. Overall seroprevalence rate in children world-wide was estimated to be ~33%, but this seroprevalence rate is decreasing in the developed world for both adults and children. It is acquired in childhood and can persist through colonization throughout life if untreated. Fortunately, it often is asymptomatic and generally does not cause serious disease in children. Some serotyping data shows that within families children acquire it more...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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