Renal functional recovery among inpatients: A plausible marker of reduced renal functional reserve

Clin Exp Pharmacol Physiol. 2021 Sep 20. doi: 10.1111/1440-1681.13545. Online ahead of print.ABSTRACTRenal functional reserve (RFR) reflects the ability of the kidney to enhance glomerular filtration rate (GFR) in response to a protein load. Chronic kidney disease (CKD) leads to diminished RFR, since the capacity for whole-body GFR to increase through hyperfiltration of remaining nephrons is limited. Evaluating 41,456 inpatients following computerised tomography we reported many exhibiting acute kidney injury (AKI) but more patients with recovering kidney function (AKR), presumably reflecting resolution of their critical conditions. The incidences of AKI and AKR were closely co-associated and were both inversely correlated with baseline kidney function. We discuss this phenomenon, arguing that AKR among inpatients with an acute illness, like AKI, may often reflect underlying subtle CKD with diminished RFR.PMID:34545593 | DOI:10.1111/1440-1681.13545

Source: Clinical and Experimental Pharmacology and Physiology - September 21, 2021 Category: Drugs & Pharmacology Authors: Yuri Gorelik Mogher Khamaisi Zaid Abassi Roger G Evans Samuel N Heyman Source Type: research