Influence of Pregnancy-Related Conditions on Human Epididymis Protein 4 Serum Levels in Comparison to CA  125 - a Prospective Cohort Trial

Conclusions HE4 serum levels are influenced by several pregnancy-related conditions leading to significantly higher levels in these cases. Despite differing medians according to trimester, the 95th percentile cut-offs and almost all maximum values during the entire course of pregnancy were below the established cut-off for premenopausal women. It was also superior to the performance of ROMA index. Therefore, HE4 can be used as a valuable negative predictive marker for the assessment of adnexal masses during pregnancy.PMID:34531611 | PMC:PMC8437581 | DOI:10.1055/a-1475-4296
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Authors: Source Type: research