The prognostic significance of HPV, p16, and p53 protein expression in vaginal cancer: A systematic review

ConclusionsThis systematic review suggests that women with HPV- and p16-positive vaginal cancer have an improved prognosis compared with those with HPV- or p16-negative vaginal cancer. Results for p53 were varied, and no conclusion could be reached. Only 12 studies could be included in the review, of which most were based on small populations. Hence, further and larger studies on the prognostic impact of HPV, p16, and p53 in vaginal cancer are warranted.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: SYSTEMATIC REVIEW Source Type: research

Related Links:

CONCLUSION: DSS rate was 54.0 ± 6.8% and the OS rate did not exceed 31.9 ± 6.8%. Rural residence was not associated with late stage at diagnosis or receipt of treatment.PMID:34567252 | PMC:PMC8426020 | DOI:10.3332/ecancer.2021.1267
Source: Ecancermedicalscience - Category: Cancer & Oncology Authors: Source Type: research
Conclusion The tumor SUV of FLT at diagnosis was lower than that of FDGPET. FLT uptake was markedly decreased after chemoRT. Results indicate that there may not be a significant effect of inflammation on FLT uptake in gynecologic cancers. FLT may be a useful tool when assessing the effects of chemoRT on gynecologic malignancies and planning for postchemoRT brachytherapy treatments.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Abstract A sarcoid‐like reaction is a development of non‐caseating granuloma in patients with underlying malignancy and represents a false positive finding on positron emission tomography/computed tomography (PET/CT). A sarcoid‐like reaction is a benign condition; therefore, differentiating a sarcoid‐like reaction from cancer recurrence is necessary. Only uterine and ovarian cancer related cases have been reported in the gynecological field and to the best of our knowledge, this is the first case of a sarcoid‐like reaction in vaginal cancer. A 59‐year‐old vaginal cancer patient received concurrent chemoradiot...
Source: Journal of Obstetrics and Gynaecology Research - Category: OBGYN Authors: Tags: Case Report Source Type: research
Publication date: Available online 4 March 2015 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Shalini Rajaram , Amita Maheshwari , Astha Srivastava Vaginal cancer is a rare cancer comprising about 3% of all gynecologic cancers. Primary vaginal cancer should be carefully assigned as spread from cervix, vulva, and other metastatic tumors to vagina can occur. Although vaginal cancer traditionally occurs in older postmenopausal women, the incidence of high-risk human papillomavirus (HPV)-induced cancers is increasing in younger women. Squamous cell carcinoma is still the most common his...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Databases & Libraries | OBGYN | PET Scan | Squamous Cell Carcinoma | Study | Vaginal Cancer | Women