Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212)

CONCLUSION: In RAS wild-type metastatic colorectal cancer, maintenance therapy with FU/FA plus Pmab induced a significantly superior PFS compared with FU/FA alone. If active maintenance therapy is aspired following induction therapy with FU/FA and oxaliplatin plus Pmab, FU/FA plus Pmab appears to be the most favorable option.PMID:34533973 | DOI:10.1200/JCO.21.01332

Source: Clinical Colorectal Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Dominik Paul Modest Meinolf Karthaus Stefan Fruehauf Ullrich Graeven Lothar M üller Alexander Otto K önig Ludwig Fischer von Weikersthal Karel Caca Albrecht Kretzschmar Eray Goekkurt Siegfried Haas Annika Kurreck Arndt Stahler Swantje Held Armin Jarosch Source Type: research