CCL2-CCR2 signaling in the skin drives surfactant-induced irritant contact dermatitis via IL-1 β-mediated neutrophil accumulation

Surfactant-induced cumulative irritant contact dermatitis (ICD) is a common and clinically important skin disorder. CCL2 is known to mediate inflammation following tissue damage in various organs. Thus, we investigated whether and how CCL2 contributes to the development of murine cumulative ICD induced by a common surfactant, sodium dodecyl sulfate (SDS). Wild-type mice treated topically with SDS for 6 consecutive days developed skin inflammation that recapitulated the features of human cumulative ICD, including barrier disruption, epidermal thickening, and neutrophil accumulation.

Source: Journal of Investigative Dermatology - September 21, 2021 Category: Dermatology Authors: Rintaro Shibuya, Yoshihiro Ishida, Sho Hanakawa, Tatsuki R. Kataoka, Yasuhide Takeuchi, Teruasa Murata, Arisa Akagi, Zachary Chow, Toshiaki Kogame, Satoshi Nakamizo, Saeko Nakajima, Gyohei Egawa, Takashi Nomura, Naotomo Kambe, Akihiko Kitoh, Kenji Kabashi Tags: Original Article Source Type: research