MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer

ConclusionTaken together, miR-143-3p and miR-495-3p co-target CDK1, thereby inhibiting the occurrence and development of cervical cancer.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Condition:   Cervical Cancer Intervention:   Combination Product: Toripalimab Combined With Concurrent Platinum-based Chemoradiotherapy Sponsor:   Tianjin Medical University Cancer Institute and Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsOur comprehensive analysis of cervical screening documents provided by Italian regions showed an alarming lack of specific indications on the execution of screening Pap smears in pregnant women. Clear indications should instead be widely available to screening staff, in order to appropriately perform cervical screening of pregnant women.Key messagesOnly a minority of the Italian regions explicitly included indications for Pap smear execution during pregnancy.The presence of these indications is strongly warranted as it would allow timely, safe, and appropriate cervical screening also for pregnant women.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
AbstractBackgroundThe Breast Cancer (BCS) and Colorectal Cancer (CRCS) screening programmes are consolidated in the Basque Country with coverage and participation rates according to EU recommendations. The Cervical Cancer Screening (CCS) carried out in 2018 achieved an appropriate migration from an opportunistic programme an coverage in 2019. The pandemic disrupted the invitations and participation because of the lockdown and procedures offered because of Covid-19 safety measures since then. Objective: Analysis of the expected impact of the pandemic on early detection of advanced lesions and cancer.MethodsRetrospective coh...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsThe majority of women in our sample know why they should do the Pap test; however, they need to be further informed with additional details about the diagnostic test. Although most of the women were aware about the importance of testing, one third of them were not regularly tested for cervical cancer detection or had lacked knowledge about vaccination.Key messagesA high percentage of women is aware about the benefits of cervical cancer screening.However, information campaigns and establishment of national screening programs are required to facilitate the access to such programs for all women.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsHIPE data is limited by duplicate episodes of care, and it is recognised that smoking documentation may be an underestimate. However, it is useful to analyse trends, as these limitations should be stable over the 5-year study period. Rates remain high; our further research will document barriers and facilitators to smoking cessation among cancer patients.Key messagesSmoking rates in cancer patients are high despite proven benefits of smoking cessation.Supportive smoking cessation services as part of routine cancer care are indicated.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Abstract In Pakistan, cervical cancer is the third most frequent cancer among women. Most cases are caused by sexually-acquired infection with human papillomaviruses (HPV). Vaccination of adolescent girls against HPV significantly reduces the incidence of cervical cancer. HPV vaccination is available in Pakistan, but plans to develop a HPV vaccination program are currently at a very early stage. We conducted a formative study to explore adolescent girls' perspectives on HPV and cervical cancer, and collected their recommendations for implementing an HPV vaccination program. We conducted qualitative focus group discuss...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsThe study showed the feasibility and high acceptance of HPV self-sampling among long-term screening nonattenders in Estonia. As a next step, self-sampling will be piloted in organized screening program to identify optimal dissemination strategy.Key messagesHPV self-sampling in Estonia is feasible, well accepted and has the potential for improving screening uptake among hard-to-reach women.Self-sampling strategy will be further tested within cervical cancer screening program.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsThe study confirmed the importance of screening in preventing CC, also revealing the independent effect of several social factors on CC risk. To reduce CC incidence in Estonia, immediate efforts are necessary to increase the effectiveness of screening, particularly among high-risk and hard-to-reach women.Key messagesThis case-control study of cervical cancer in Estonia identified high-risk groups: women with no Pap-smears, interruptions in health insurance, low education, and living outside the capital city area.Reduction in cervical cancer incidence in Estonia can be achieved through more effective screening an...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
AbstractBackgroundIn 2006, Estonia started organized nationwide cervical cancer (CC) screening program, but in 2020 incidence of CC in was still second highest in Europe. An estimated 80% of women have done Pap tests outside the organized screening program. The aim of this study was (1) to describe the trend in lifetime uptake of Pap test and (2) to explore trends in lifetime uptake of Pap test by age group, nationality and education among 25-64-years-old women in Estonia based on data from 2004 to 2020.MethodsData of 6685 women aged 25-64 years who participated in population-based cross-sectional surveys of Health Behavio...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
This study aims to evaluate the expression of circulating microRNAs (miRNAs) in MM patients and to correlate those levels with clinicopathological features, including bone lesions. A panel of miRNAs associated with MM onset and progression, or with bone remodeling, was analyzed in the plasma of 82 subjects (47 MM patients; 35 healthy controls). Results show that miR-16-5p, miR-20a-5p, and miR-21-5p are differently expressed between MM patients and healthy controls. Receiver operating characteristic analyses indicate that their combined expression has potential as a molecular marker (Area Under the Curve, AUC of 0.8249). Fu...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Cervical Cancer | Databases & Libraries | Genetics | Study