Social disruption –induced stress pre-exposure aggravates, while the presence of conspecifics diminishes, acetic acid–induced writhing

ConclusionsThese findings suggest that social disruption –induced stress pre-exposure may upregulate accumbal TRPV1 receptor expression and consequently aggravate acid-induced writhing. Group testing prevents such stress pre-exposure escalation of acid-induced writhing most likely by strengthening the GABAergic inhibition on local neural activity in the medial septum.

http://link.springer.com/10.1007/s00213-021-05901-z

Source: Psychopharmacology - September 21, 2021 Category: Psychiatry Source Type: research