Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

Activity-driven changes in the neuronal surface glycoproteome are known to occur with synapse formation, plasticity and related diseases, but their mechanistic basis and significance are unclear. Here, we observed thatN-glycans on surface glycoproteins of dendrites shift from immature to mature forms containing sialic acid in response to increased neuronal activation. In exploring the basis of theseN-glycosylation alterations, we discovered they result from the growth and proliferation of Golgi satellites scattered throughout the dendrite. Golgi satellites that formed during neuronal excitation were in close association with ER exit sites and early endosomes and contained glycosylation machinery without the Golgi structural protein, GM130. They functioned as distal glycosylation stations in dendrites, terminally modifying sugars either on newly synthesized glycoproteins passing through the secretory pathway, or on surface glycoproteins taken up from the endocytic pathway. These activities led to major changes in the dendritic surface of excited neurons, impacting binding and uptake of lectins, as well as causing functional changes in neurotransmitter receptors such as nicotinic acetylcholine receptors. Neural activity thus boosts the activity of the dendrite ’s satellite micro-secretory system by redistributing Golgi enzymes involved in glycan modifications into peripheral Golgi satellites. This remodeling of the neuronal surface has potential significance for synaptic ...
Source: eLife - Category: Biomedical Science Tags: Cell Biology Neuroscience Source Type: research

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Nurse and technicians at Eagleville Hospital have avoided a potential strike, reaching terms of a new three-year contract that includes wages and staffing improvements. The 110 staff members at the 305-bed Montgomery County behavioral health and addictions treatment medical center, represented by the Pennsylvania Association of Staff Nurses and Allied Professionals (PASNAP), had voted earlier this month to authorize a strike citing concerns about what they said w ere unsafe staffing levels. In…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Condition:   Problem Gambling Intervention:   Other: Online therapy Sponsors:   Centre for Addiction and Mental Health;   Ontario Ministry of Health and Long Term Care Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Major Depressive Disorder Intervention:   Other: eCARIBOU Sponsors:   Centre for Addiction and Mental Health;   York University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: An ACS reportedly supports hospitalists and medical staff to best care for hospitalized patients with OUD. Notably, care provided to patients with OUD may not be uniform depending on various physician-level factors. Future work to address the concerns reported by study participants may include education for OUD treatment, early involvement of the ACS, and incorporation of buprenorphine prescribing algorithms to standardize care.PMID:34666634 | DOI:10.1080/08897077.2021.1975873
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
This study examined the prospective association of physical exertion at work with risk of tobacco, cannabis, alcohol use and sugar and fat consumption.MethodsVolunteers of the French population-based CONSTANCES cohort currently employed were included from 2012 to 2017 for tobacco and cannabis outcomes (n = 100,612), and from 2012 to 2016 for alcohol and sugar and fat outcomes (n = 75,414). High level of physical exertion was defined as a score ≥12 at the Rating Perceived Exertion Borg scale. Substance use was self-reported and patterns of sugar and fat intakes were obtained from principal component analysis and used in ...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Abstract The life expectancy gap between Russia and post-industrial countries is mainly due to mortality from diseases of the circulatory system (DCS), primarily in working ages, substantiating the need for a program to reduce cardiovascular mortality, currently implemented in Russia. In general, this program has resulted in a multiple reduction in cardiovascular mortality in Russia, however, in 2015-2017, Moscow turned out to be the absolute outsider among the Russian regions in DCS mortality among males of young and middle working ages and a contrastive outsider among females: in ages 15-29 mortality increased 4.4-f...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
AbstractBackgroundSmoking is an established risk factor for cardiovascular events, such as myocardial infarction, stroke and cardiovascular death. Although the harmful effects of smoking on health are widely known. Smoking is highly addictive and cessation can be extremely difficult, even after a life-threatening vascular event.ObjectiveThe present study aimed to assess the relation between smoking status and risk of recurrent Cardiovascular events 5 years after the first hospitalization for acute coronary syndrome.MethodsA cross sectional study was conducted in the Smoking Cessation Service at University Hospital of Monas...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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Source: Substance Abuse - Category: Addiction Authors: Source Type: research
Conclusions: This study suggests that although IGA has been regarded as a mental disease, online game behavior should be treated differently. Online game activities should not be entirely denied, but mental disorders caused by excessive gaming activities deserve attention. In particular, the emotional state and executive function of students with excessive online game behaviors should be monitored and intervened in advance to avoid game behaviors turning into indulgent behaviors or addiction. As a cognitive control process, executive function may play a key role in regulating IGA and emotional state.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionsThe findings have implications for identifying the risk factors of co-occurring addictive behaviors, and the development of primary prevention strategies resulting from such factorsKey messagesThe prevalence of addictive behavior is very high in middle school students.Understanding the risk factors of co-occurrence addictive problems is important for prevention program planning.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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