Primary Mediastinal B-Cell Lymphoma: The Role of Consolidative Radiation for a “Terrible” Lymphoma

A 26-year-old male presented with shortness of breath, cough, and chest pain with a 2-year history of diffuse skin lesions. He underwent evaluation with computed tomography (CT) and follow-up positron emission tomography (PET)/CT imaging, identifying a 17.3 × 8.0 cm anterior mediastinal mass (Fig. 1A). Biopsy identified a diffuse large B-cell lymphoma, positive for CD45, CD20, and CD23 with a Ki-67 of 35%. There was partial positivity of BC-6 and CD30. The biopsy was negative for CD10, CD15, C-MYC, CD5, CD13, and EBER.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research