The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in < em > Mycobacterium abscessus < /em >

Antimicrob Agents Chemother. 2021 Sep 20:AAC0096421. doi: 10.1128/AAC.00964-21. Online ahead of print.ABSTRACTThe anti-tuberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 is not only ineffective against M. abscessus in vitro, it also does not potentiate the activity of clofazimine.PMID:34543090 | DOI:10.1128/AAC.00964-21
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research