SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer

This study presents that SIRT6 silencing overcomes sorafenib resistance by promoting ferroptosis, which is a novel form of cell death. Mechanistically, SIRT6 inhibition led to the inactivation of the Keap1/Nrf2 signalling pathway and downregulation of GPX4. The overexpression of GPX4 or activation of Keap1/Nrf2 reverses the effects of the downregulation of SIRT6 on sorafenib-induced ferroptosis. Thus, targeting the SIRT6/Keap1/Nrf2/GPX4 signalling pathway may be a potential strategy for overcoming sorafenib resistance in GC.PMID:34530350 | DOI:10.1016/j.bbrc.2021.08.080
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research