Ignored Papers, Invented Quotations: A History of Fetal Alcohol Syndrome

Neonatology. 2021 Sep 14:1-7. doi: 10.1159/000518534. Online ahead of print.ABSTRACTGiven the high rate of alcoholism throughout history, its effects on the fetus may have existed for millennia. But, the claim that Greeks and Romans were aware of fetal alcohol syndrome rests on incorrect citations. From 1725, maternal alcohol consumption was associated with retarded fetal growth and neurological anomalies. From 1809, scientists followed Lamarck's theory that the disorders parents acquire during their lifetime are passed on to their offspring. Fetal effects were thought to be inherited mainly from the father. During the 19th century, parental alcoholism became associated with malformations. In 1915, Ballantyne distinguished genetic influence via germ cells from toxin's effect on the embryo. Fetal alcohol syndrome was characterized by Rouquette [Influence de la toxicomanie alcoolique parentale sur le développement physique et psychique des jeunes enfants] in 1957 and Lemoine et al. [Ouest Medical. 1968;21:476-482] in 1968 as consisting of 4 features: (A) facial anomalies (narrow forehead, retracted upper lip, and cupped ears), (B) severe growth retardation (prenatal and postnatal), (C) malformations (limbs, cardiac, and visceral), and (D) central nervous system anomalies (hyperexcitability and mental retardation). But, their studies, written in French, remained disregarded. In 1973, Jones et al. [Lancet. 1973;302:999-1001] reported "the first association between mat...
Source: Neonatology - Category: Perinatology & Neonatology Authors: Source Type: research

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AbstractThe purpose of this study was to describe the profile of individual, relational, and contextual resilience resources reported by youth with FASD and their caregivers and examine how these resources related to early childhood adversity, potential protective factors, and concurrent emotional and behavioral functioning. Nineteen youth with FASD (aged 13 to 23  years) and their caregivers (foster or adoptive parents) completed the Child and Youth Resilience Measure (CYRM-28), the Behavioral Assessment System for Children (BASC-2), and a detailed developmental history questionnaire. Youth with FASD were reported to...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
CONCLUSIONS: FASD was found to be common in these schools and most of these children's needs had not previously been identified. A larger, more definitive study that uses a random sampling technique stratified by deprivation level to select schools is needed to make inferences regarding the population prevalence of FASD.PMID:34590329 | DOI:10.1111/acer.14705
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research
CONCLUSIONS: These results identify an evolutionarily conserved role of Tp53 as a pathogenic mechanism for alcohol-induced teratogenesis.PMID:34581462 | DOI:10.1111/acer.14688
Source: Cell Research - Category: Cytology Authors: Source Type: research
Contributors : Bonnie L Alberry ; Aniruddho Chokroborty Hoque ; Shiva M SinghSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMaternal alcohol consumption during pregnancy results in a spectrum of lifelong behavioral and cognitive deficits collectively known as Fetal Alcohol Spectrum Disorders (FASD). FASD is a major health burden in most societies, there is no cure, and the molecular mechanism involved in its development is poorly understood. Human neurodevelopment is a continuum that extends over two decades after birth, with the potential to influence outcomes both prenatally and po...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
CONCLUSION: These findings are in keeping with FASD prevalence studies that used similar passive surveillance methods. They provide a starting point to better understanding the prevalence and burden of FASD in Canada.PMID:34549919 | DOI:10.24095/hpcdp.40.9.05
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Authors: Source Type: research
AbstractGlobal trends of increasing alcohol consumption among women of childbearing age, social acceptability of women ’s alcohol use, as well as recent changes in alcohol use patterns due to the COVID-19 pandemic may put many pregnancies at higher risk for prenatal alcohol exposure (PAE), which can cause fetal alcohol spectrum disorder (FASD). Therefore, screening of pregnant women for alcohol use has become more important than ever and should be a public health priority. This narrative review presents the state of the science on various existing prenatal alcohol use screening strategies, including the clinical util...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
Neonatology. 2021 Sep 14:1-7. doi: 10.1159/000518534. Online ahead of print.ABSTRACTGiven the high rate of alcoholism throughout history, its effects on the fetus may have existed for millennia. But, the claim that Greeks and Romans were aware of fetal alcohol syndrome rests on incorrect citations. From 1725, maternal alcohol consumption was associated with retarded fetal growth and neurological anomalies. From 1809, scientists followed Lamarck's theory that the disorders parents acquire during their lifetime are passed on to their offspring. Fetal effects were thought to be inherited mainly from the father. During the 19t...
Source: Neonatology - Category: Perinatology & Neonatology Authors: Source Type: research
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