FDA approved gout medicine - Probenecid - shows promise fighting viruses like COVID-19

Probenecid, a drug used to treat gout, has shown anti-viral capabilities, a study from the University of Georgia finds. It is among a variety of drugs being tested to treat COVID-19.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Eur J Intern Med. 2021 Oct 14:S0953-6205(21)00332-0. doi: 10.1016/j.ejim.2021.10.002. Online ahead of print.ABSTRACTColchicine is an old, inexpensive, and relatively safe anti-inflammatory drug traditionally used in gout and over the last 50 years in familial Mediterranean fever. A search of all high-hierarchy studies (randomized controlled trials [RCTs], systematic reviews and meta-analysis of RCTs) over the last 20 years revealed myriad other evidence-based applications. Colchicine seems efficacious in the treatment of acute pericarditis and prevention of recurrences and the prevention of postcardiac injury syndrome and ...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Source Type: research
Cardiol J. 2021 Oct 13. doi: 10.5603/CJ.a2021.0123. Online ahead of print.ABSTRACTColchicine is an effective anti-inflammatory agent used to treat gout, coronary artery disease, viral pericarditis, and familial Mediterranean fever. It has been found to act by preventing the polymerization of the protein called tubulin, thus inhibiting inflammasome activation, proinflammatory chemokines, and cellular adhesion molecules. Accumulating evidence suggests that some patients with coronavirus disease 2019 (COVID-19) suffer from "cytokine storm" syndrome. The ideal anti-inflammatory in this setting would be one that is re...
Source: Cardiology Journal - Category: Cardiology Authors: Source Type: research
Is colchicine an effective treatment for people with COVID-19?Colchicine was debated to be a potential treatment option for COVID-19, hoping that the medication ’s anti-inflammatory properties could prevent or reduce a dysregulated immune response.Although there are completed studies without publication and diverse ongoing studies that could change our findings, the current evidence taken from 3 studies is moderate that colchicine makes no difference for people with moderate to severe disease. The safety of the medication remained unclear- given the restricted dosage range and the inconsistent reporting of (serious) ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
THE UNPRECEDENTED scale of the vaccine rollout has proven an effective shield against infection. For those who do become infected and become seriously ill, however, current go-to treatments are massively limited. One new study has suggested the gout drug remdesivir could be a prime candidate to treat severely ill COVID-19 patients.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This article summarizes the top 20 research studies of 2020 identified as POEMs (patient-oriented evidence that matters), including the two most highly rated guidelines of the year on gout and chronic obstructive pulmonary disease (COPD). Regarding COVID-19, handwashing and social distancing through stay-at-home orders or quarantine measures are effective at slowing the spread of illness. Use of proper face masks (not gaiters or bandanas) is also effective at preventing trans- mission. This is important because the virus can infect others during the presymptomatic phase. Aspirin can no longer be recommended for the primary...
Source: American Family Physician - Category: Primary Care Authors: Source Type: research
AbstractCurrent data demonstrated that severe cases of coronavirus-disease-19 (COVID-19) require treatment with antiviral therapy, dexamethasone, supportive care, as well as some anti-rheumatic drugs, among them, cytokine inhibitors and colchicine. Colchicine is an anti-inflammatory drug that is being used in rheumatology for many years to treat mostly gout, calcium pyrophosphate deposition disease, and Familial Mediterranean Fever. Here, we present for the first time, two patients suffering from gout being treated with colchicine, who were affected from severe acute respiratory coronavirus-2 (SARS-CoV-2) syndrome. Both pa...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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