Reducing tumor invasiveness by ramucirumab and TGF ‐β receptor kinase inhibitor in a diffuse‐type gastric cancer patient‐derived cell model

ConclusionsIn this study, we showed TEW-7197 and ramucirumab considerably decreased invasiveness, thus EMTness in a panel of diffuse-type GC cell lines including GC PDCs. Taken together, we confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model.

Source: Cancer Medicine - September 21, 2021 Category: Cancer & Oncology Authors: Song ‐Yi Lee, Seonggyu Byeon, Jihoon Ko, Sujin Hyung, In‐Kyoung Lee, Noo Li Jeon, Jung Yong Hong, Seung Tae Kim, Se Hoon Park, Jeeyun Lee Tags: RESEARCH ARTICLE Source Type: research