Subpathologies and genomic classifier for treatment individualization of post-prostatectomy radiotherapy

CONCLUSIONS: IDC/CA subpathologies and GC predict for biochemical relapse and metastasis beyond conventional clinicopathologic indexes in the PORT setting. Patients harboring IDC/CA are at higher risk of relapse after maximal local therapies, thus warranting consideration for treatment intensification strategies. Conversely, for men with absence of IDC/CA and low GC scores, de-intensification strategies could be explored.PMID:34538726 | DOI:10.1016/j.urolonc.2021.08.013

Source: Urologic Oncology - September 20, 2021 Category: Urology & Nephrology Authors: Matthew Ramotar Melvin L K Chua Hong Truong Ali Hosni Melania Pintilie Elai Davicioni Neil E Fleshner Adam P Dicker Robert G Bristow Hansen H He Theo van der Kwast Robert B Den Alejandro Berlin Source Type: research