Association of comorbidity between < i > Opisthorchis viverrini < /i > infection and diabetes mellitus in the development of cholangiocarcinoma among a high-risk population, northeastern Thailand

This study aimed to assess the correlation of CCA with various combinations ofO.viverrini infection and DM among a high-risk population in northeastern Thailand. MethodologyThis study included participants from 20 provinces in northeastern Thailand who had been screened for CCA in the Cholangiocarcinoma Screening and Care Program (CASCAP) between 2013 and 2019. Histories ofO.viverrini infection and DM diagnosis were obtained using a health questionnaire. CCA screening used ultrasonography with a definitive diagnosis based on histopathology. Multilevel mixed-effects logistic regression was performed to quantify the association, which is presented as adjusted odds ratios (aOR) and their 95% confidence intervals (CI). Principal findingsOverall, 263,776 participants were included, of whom 32.4% were infected withO.viverrini, 8.2% were diagnosed with DM, and 2.9% had a history of bothO.viverrini infection and DM. The overall rate of CCA was 0.36%. Of those infected withO.viverrini, 0.47% had CCA; among those with DM, 0.59% had CCA and among those infected withO.viverrini and had DM, 0.73% had CCA. Compared with participants who were not infected withO.viverrini and were non-DM, the aOR for those infected withO.viverrini and with DM was 2.36 (95% CI: 1.74 –3.21; p-value
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research