Viruses, Vol. 13, Pages 1878: Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity
Viruses, Vol. 13, Pages 1878: Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity
Viruses doi: 10.3390/v13091878
Authors:
Karla Ausderau
Sabrina Kabakov
Elaina Razo
Ann M. Mitzey
Kathryn M. Bach
Chelsea M. Crooks
Natalie Dulaney
Logan Keding
Cristhian Salas-Quinchucua
Lex G. Medina-Magües
Andrea M. Weiler
Mason Bliss
Jens Eickhoff
Heather A. Simmons
Andres Mejia
Kathleen M. Antony
Terry Morgan
Saverio Capuano III
Mary L. Schneider
Matthew T. Aliota
Thomas C. Friedrich
David H. O’Connor
Thaddeus G. Golos
Emma L. Mohr
Infants exposed to Zika virus (ZIKV) prenatally may develop birth defects, developmental deficits, or remain asymptomatic. It is unclear why some infants are more affected than others, although enhancement of maternal ZIKV infection via immunity to an antigenically similar virus, dengue virus (DENV), may play a role. We hypothesized that DENV immunity may worsen prenatal ZIKV infection and developmental deficits in offspring. We utilized a translational macaque model to examine how maternal DENV immunity influences ZIKV-exposed infant macaque neurodevelopment in the first month of life. We inoculated eight macaques with prior DENV infection with ZIKV, five macaques with ZIKV, and four macaques with saline. DENV/ZIKV-exposed infants had significantly worse visual orientation skills than ZIKV-exposed infants whose mothers were DENV-naive, with no differences in motor, sen...
Source: Viruses - Category: Virology Authors: Karla Ausderau Sabrina Kabakov Elaina Razo Ann M. Mitzey Kathryn M. Bach Chelsea M. Crooks Natalie Dulaney Logan Keding Cristhian Salas-Quinchucua Lex G. Medina-Mag ües Andrea M. Weiler Mason Bliss Jens Eickhoff Heather A. Simmons Andres Mejia Kathleen M Tags: Article Source Type: research
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