Viruses, Vol. 13, Pages 1878: Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity

Viruses, Vol. 13, Pages 1878: Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity Viruses doi: 10.3390/v13091878 Authors: Karla Ausderau Sabrina Kabakov Elaina Razo Ann M. Mitzey Kathryn M. Bach Chelsea M. Crooks Natalie Dulaney Logan Keding Cristhian Salas-Quinchucua Lex G. Medina-Magües Andrea M. Weiler Mason Bliss Jens Eickhoff Heather A. Simmons Andres Mejia Kathleen M. Antony Terry Morgan Saverio Capuano III Mary L. Schneider Matthew T. Aliota Thomas C. Friedrich David H. O’Connor Thaddeus G. Golos Emma L. Mohr Infants exposed to Zika virus (ZIKV) prenatally may develop birth defects, developmental deficits, or remain asymptomatic. It is unclear why some infants are more affected than others, although enhancement of maternal ZIKV infection via immunity to an antigenically similar virus, dengue virus (DENV), may play a role. We hypothesized that DENV immunity may worsen prenatal ZIKV infection and developmental deficits in offspring. We utilized a translational macaque model to examine how maternal DENV immunity influences ZIKV-exposed infant macaque neurodevelopment in the first month of life. We inoculated eight macaques with prior DENV infection with ZIKV, five macaques with ZIKV, and four macaques with saline. DENV/ZIKV-exposed infants had significantly worse visual orientation skills than ZIKV-exposed infants whose mothers were DENV-naive, with no differences in motor, sen...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research