Viruses, Vol. 13, Pages 1879: The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients

Viruses, Vol. 13, Pages 1879: The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients Viruses doi: 10.3390/v13091879 Authors: Dęborska-Materkowska Kamińska Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an enormous rise in scientific response with an excess of COVID-19-related studies on the pathogenesis and potential therapeutic approaches. Solid organ transplant (SOT) recipients are a heterogeneous population with long-lasting immunosuppression as a joining element. Immunocompromised patients are a vulnerable population with a high risk of severe infections and an increased infection-related mortality rate. It was postulated that the hyperinflammatory state due to cytokine release syndrome during severe COVID-19 could be alleviated by immunosuppressive therapy in SOT patients. On the other hand, it was previously established that T cell-mediated immunity, which is significantly weakened in SOT recipients, is the main component of antiviral immune responses. In this paper, we present the current state of science on COVID-19 immunology in relation to solid organ transplantation with prospective therapeutic and vaccination strategies in this population.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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