Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors' Target Prediction

CONCLUSION: We identified novel variants associated with HF and CKD using effectively incorporating information from different GWAS datasets. Our analysis may provide new insights into HF and CKD therapeutic approaches based on the pleiotropic genes, common targets, and mechanisms by integrating the metaCCA method, TWAS and VEGAS2 analyses, and target prediction of SGLT2 inhibitors.PMID:34540994 | PMC:PMC8443964 | DOI:10.1155/2021/4229194

Source: Biomed Res - September 20, 2021 Category: Research Authors: Huanqiang Li Ziling Mai Sijia Yu Bo Wang Wenguang Lai Guanzhong Chen Chunyun Zhou Jin Liu Yongquan Yang Shiqun Chen Yong Liu Jiyan Chen Source Type: research