Application of Genetic Algorithm-Based Support Vector Machine in Identification of Gene Expression Signatures for Psoriasis Classification: A Hybrid Model

CONCLUSIONS: The results showed that the genetic algorithm improved the SVM classifier performance significantly implying the ability of the proposed model in terms of detecting relevant gene expression signatures as the best features.PMID:34540995 | PMC:PMC8443357 | DOI:10.1155/2021/5520710
Source: Biomed Res - Category: Research Authors: Source Type: research

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Psoriasis is a common chronic recurrent inflammatory skin disease. The pathogenesis of psoriasis, such as other autoimmune diseases, is still unclear, which brings great difficulties to the treatment. This stu...
Source: BioMedical Engineering OnLine - Category: Biomedical Engineering Authors: Tags: Research Source Type: research
This study aimed to evaluate the relationship between GDF-15 serum levels as well as gene expression with psoriasis and its severity. This case-control study was performed on 45 patients with psoriasis Vulgaris and 45 healthy individuals. The severity of the disease was determined based on the psoriasis area and severity index (PASI score). Serum levels of GDF-15 were measured by enzyme-linked immunosorbent assay (ELISA) and its gene expression in peripheral blood mononuclear cells was quantified by real-time polymerase chain reaction (RT-PCR). The mean serum levels of GDF-15 in patients and controls were 1.98±1.57 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Chronic inflammatory disorders (CID), such as autoimmune diseases, are characterized by overactivation of the immune system and loss of immune tolerance. T helper 17 (Th17) cells are strongly associated with the pathogenesis of multiple CID, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. In line with the increasingly recognized contribution of innate immune cells to the modulation of dendritic cell (DC) function and DC-driven adaptive immune responses, we recently showed that neutrophils are required for DC-driven Th17 cell differentiation from human naive T cells. Consequently, recruitment of n...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Psoriasis is a T-cell mediated autoimmune disease characterized by increased keratinocyte proliferation. In psoriasis, chemokines are secreted by a wide variety of cells (e.g. keratinocytes, dendritic cells, monocytes), which migrate immune cells (Th17 cells, Th1 cells, neutrophils, etc.) involved in the pathogenesis. Bath-psoralen plus ultraviolet A (PUVA) treatment is an established phototherapy for psoriasis, but its effects on chemokine levels remain unknown. We measured the levels of 22 serum chemokines by using a flow cytometry bead-based immunoassay in 20 psoriasis patients first treated with bath-PUVA therapy betwe...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research
Anti-TNFs have become a benchmark in the treatment of numerous autoimmune diseases such as rheumatoid arthritis, Crohn ’s disease, and psoriasis. However, TNF blockade as a therapy has its limitations. Besides an increased susceptibility to infections, 0.2-1% of patients develop anti-TNF induced lupus erythematosus (ATIL). Moreover, anti-TNFs are associated with increased frequencies of anti-drug antibodies (ADA). We have previously shown that TNF inhibition shifts the equilibrium of TNF and type I interferons towards an excessive type I interferon response.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research
ConclusionsOur retrospective population-based cohort study showed that the prescription of proton pump inhibitors is associated with a higher risk of ADs.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
J Immunol. 2021 Sep 27:ji2100686. doi: 10.4049/jimmunol.2100686. Online ahead of print.ABSTRACTAutoimmune diseases develop when autoantigens activate previously quiescent self-reactive lymphocytes. Gene-gene interaction between certain HLA class I risk alleles and variants of the endoplasmic reticulum aminopeptidase ERAP1 controls the risk for common immune-mediated diseases, including psoriasis, ankylosing spondylitis, and Behçet disease. The functional mechanisms underlying this statistical association are unknown. In psoriasis, HLA-C*06:02 mediates an autoimmune response against melanocytes by autoantigen present...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
CONCLUSION: Our findings suggested that fungal pathogens, particularly dermatophytes, may play an important role in the pathogenicity of psoriasis. Also, due to the high rate of yeast colonization in the clinical samples of psoriatic patients, concomitant use of anti-inflammatory drugs and antifungals may represent an effective therapeutic approach for better management of chronic lesions among these patients. Mycological tests should be applied to indicate the incidence of fungal diseases in psoriatic patients.PMID:34567800 | PMC:PMC8461225 | DOI:10.1155/2021/1174748
Source: Autoimmune Diseases - Category: Allergy & Immunology Authors: Source Type: research
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