Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus [Neuroscience]
The biological mechanisms underpinning learning are unclear. Mounting evidence has suggested that adult hippocampal neurogenesis is involved although a causal relationship has not been well defined. Here, using high-resolution genetic mapping of adult neurogenesis, combined with sequencing information, we identify follistatin (Fst) and demonstrate its involvement in learning and adult...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Yu-Ju Chen, Shin-Meng Deng, Hui-Wen Chen, Chi-Hui Tsao, Wei-Ting Chen, Sin-Jhong Cheng, Hsien-Sung Huang, Bertrand Chin-Ming Tan, Martin M. Matzuk, Jonathan Flint, Guo-Jen Huang Tags: Neuroscience Biological Sciences Source Type: research