Norrie disease protein is essential for cochlear hair cell maturation [Neuroscience]

Mutations in the gene for Norrie disease protein (Ndp) cause syndromic deafness and blindness. We show here that cochlear function in an Ndp knockout mouse deteriorated with age: At P3-P4, hair cells (HCs) showed progressive loss of Pou4f3 and Gfi1, key transcription factors for HC maturation, and Myo7a, a specialized...

Source: Proceedings of the National Academy of Sciences - September 20, 2021 Category: Science Authors: Yushi Hayashi, Hao Chiang, ChunJie Tian, Artur A. Indzhykulian, Albert S. B. Edge Tags: Neuroscience Biological Sciences Source Type: research