Factors associated with the antinuclear antibody (ANA) titer of systemic autoimmune rheumatic diseases in ANA-positive patients after treatment: a retrospective study

This study identified 31,923 patients who underwent ANA assay for SARDs screening, and a total of 1043 patients were included in the study. Approximately 16% of the patients showed a decrease in the serological ANA titer. Younger patients (  1:10,000 was associated with an increase likelihood of a decrease in the serological ANA titer compared with baseline ANA titer 1:10,000, 1:3200 and 1:1000 (P 
Source: Clinical and Experimental Medicine - Category: Research Source Type: research

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In horses, the autoimmune disease vitiligo is characterized by the loss of melanocytes and results in patchy depigmentation of the skin around the eyes, muzzle and the perianal region. Vitiligo-like depigmenta...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research Source Type: research
Anticalin® proteins have been proven as versatile clinical stage biotherapeutics. Due to their small size (∼20 kDa), they harbor a short intrinsic plasma half-life which can be extended, e.g., by fusion with IgG or Fc. However, for antagonism of co-immunostimulatory Tumor Necrosis Factor Receptor Superfamily (TNFRSF) members in therapy of autoimmune and inflammatory diseases, a monovalent, pharmacokinetically optimized Anticalin protein format that avoids receptor clustering and therefore potential activation is favored. We investigated the suitability of an affinity-improved streptococcal Albumin-Binding Doma...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This article aims to review the factors potentially contributing to fatty liver disease or glycogen storage disruption in T1D. It ends with a proposal for clinicians to approach patients with T1D and potential hepatopathy.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Central questions for organ-specific autoimmune diseases such as type 1 diabetes (T1D) are, What are the relevant self-antigens of the destructive processes and Why does the immune system become interested in them? In PNAS, Anderson et al. (1) provide more evidence that insulin and its precursors constitute a key antigen...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Immunology and Inflammation, Commentaries Commentary Source Type: research
Immunol Lett. 2021 Oct 21:S0165-2478(21)00164-4. doi: 10.1016/j.imlet.2021.10.003. Online ahead of print.ABSTRACTCadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induc...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Source Type: research
This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn’s disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn’s disease’s twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFNγ production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
J Cell Mol Med. 2021 Oct 23. doi: 10.1111/jcmm.16993. Online ahead of print.ABSTRACTT cells bearing γδ antigen receptors have been investigated as potential treatments for several diseases, including malignant tumours. However, the clinical application of γδT cells has been hampered by their relatively low abundance in vivo and the technical difficulty of inducing their differentiation from hematopoietic stem cells (HSCs) in vitro. Here, we describe a novel method for generating mouse γδT cells by co-culturing HSC-enriched bone marrow cells (HSC-eBMCs) with induced thymic epithelial cell...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Cell Metab. 2021 Oct 19:S1550-4131(21)00480-0. doi: 10.1016/j.cmet.2021.10.002. Online ahead of print.ABSTRACTAutoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactive T cells. Here, we provide unbiased analysis of the immune changes in various compartments during cold exposure and show that this energetically costly stimulus markedly ameliorates active experimental autoimmune encephalomyelitis (EAE). Cold exposure decreases MHCII on monocy...
Source: Cell Metabolism - Category: Cytology Authors: Source Type: research
The objective of this study was to determine predictors of hospitalization for COVID-19 patients from an ARD community cohort.MethodsA real setting longitudinal study (March to November 2020) in an ARD community cohort was carried out. Potential predictors of hospitalization for COVID-19 examined included (1) sociodemographic variables (age, gender, education, tobacco use, socioeconomic status, and co-inhabitants), (2) comorbidities, (3) time to COVID-19 diagnosis, and (4) ARD ’s features: clinical (disease type, disease duration, activity), treatment [corticosteroids use/doses, use of synthetic DMARDs (cDMARDs, tsDM...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractRheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting not only the synovial joints but also multiple extra-articular sites, including ankle and foot soft tissue. Hindfoot abnormalities usually follow those in the forefoot, with up to 4 out of 10 patients experiencing talalgia during their disease course. Enthesophytosis, retrocalcaneal bursitis, and plantar fasciitis are among the most common etiologies, while heel fat pad abnormalities like subcalcaneal bursitis are rare. Here, we report two cases of subcalcaneal bursitis, and the first case of heel fat pad and subcalcaneal bursa herniat...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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