Imaging of Tuberculosis in Children

Tuberculosis (TB) is highly prevalent worldwide, and it affects children and adults equally, causing significant morbidity and mortality. Imaging plays a crucial role in diagnosis and management. Knowledge of imaging modalities available, imaging manifestations of both pulmonary and extrapulmonary tuberculosis, is vital for the radiologist for timely diagnosis among children with TB.
Source: Contemporary Diagnostic Radiology - Category: Radiology Tags: ARTICLE Source Type: research

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The finding upends conventional wisdom regarding coughing, long thought to be the main route of transmission.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Tuberculosis Coughs Disease Rates Bacteria Research South Africa Source Type: news
This article is a review of the techniques for detection of interferon-gamma as a TB disease biomarker. The objective is to provide a concise assessment of the available IFN-γ detection techniques (including conventional assays, biosensors, microfluidics, and multiplex analysis) and their ability to distinguish the different stages of the TB disease.PMID:34665279 | DOI:10.1007/s00216-021-03702-z
Source: Analytical and Bioanalytical Chemistry - Category: Chemistry Authors: Source Type: research
[MSF] Hundreds of patient volunteers from four continents have enrolled in a trial that aims to find safer, shorter, and effective treatments for multidrug-resistant tuberculosis (MDR-TB), an airborne, infectious disease that has grown resistant to standard medications. A group of scientists and clinicians led by M édecins Sans Frontières (MSF), Partners In Health (PIH) and Interactive Research and Development (IRD) make up the endTB consortium conducting the groundbreaking study funded by Unitaid.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
The finding upends conventional wisdom regarding coughing, long thought to be the main route of transmission.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Tuberculosis Coughs Disease Rates Bacteria Research South Africa Source Type: news
Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c07970
Source: Journal of the American Chemical Society - Category: Chemistry Authors: Source Type: research
Disruptions in tuberculosis (TB) treatment, HIV prevention, and malaria care during the COVID-19 pandemic threaten to reverse global progress in combating the diseases, according to a report from the Global Fund.
Source: JAMA - Category: General Medicine Source Type: research
Non-coding RNAs (ncRNAs) including microRNAs (miRs) and long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in immune cells development and function. Their expression is altered in different physiological and disease conditions, hence making them attractive targets for the understanding of disease etiology and the development of adjunctive control strategies, especially within the current context of mitigated success of control measures deployed to eradicate these diseases. In this review, we summarize our current understanding of the role of ncRNAs in the etiology and control of major human tr...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
HIV-infected persons are at increased risk of developing tuberculosis and Isoniazid preventive therapy has been shown to reduce the occurrence of tuberculosis among this group of persons. M-health technology h...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Condition:   Multidrug Resistant Tuberculosis Intervention:   Other: This is a non-intervention observational study. Sponsor:   Huashan Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we have evaluated the activity of omadacycline, a new tetracycline derivative, against M. abscessus using in vitro and in vivo approaches. Omadacycline exhibited an MIC90 of 0.5 μg/ml against a panel of 32 contemporary M. abscessus clinical isolates several of which were resistant to antibiotics that are commonly used for treatment of M. abscessus disease. Omadacycline when combined with clarithromycin, azithromycin, cefdinir, rifabutin or linezolid also exhibited synergism against several M. abscessus strains and did not exhibit antagonism when combined with an additional nine antibiotics also commonly c...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research
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