Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-Resistant Epilepsy Induced by Lithium-Pilocarpine

CONCLUSION: Taken together, these correlations among drug resistance, seizure frequency, spatial memory impairment and MFS suggested the possibility of a common pathological mechanism. More studies are needed to clarify the underlying mechanism behind these correlations and the detailed role of MFS in epilepsy. The mechanism of mossy cell change may be an important target for the treatment of seizures, drug resistance and cognitive dysfunction in patients with epilepsy.PMID:34538230 | DOI:10.2174/1567202618666210917155408
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research