Outcomes of lung transplantations since implementation of need-based allocation system

Since implementation of a medical need-based allocation system of donor lungs in 2005, double-lung transplantation has been associated with better graft survival than single-lung transplantation in patients with idiopathic pulmonary fibrosis (IPF); at 5 years, there has been no survival difference between single- and double-lung transplant recipients in patients with chronic obstructive pulmonary disease (COPD), according to a study.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
In this study, we sought to further characterize ILC2s in the kidney, their location within this organ and determine their functional role in IRI using a loss-of-function approach. Here, we found that kidney ILC2s constitutively express IL-5 and are primarily located in close proximity to the renal vasculature, within the adventitia. Additionally, we demonstrate that a reduction, deficiency or depletion of ILC2s had minimal impact on the severity of IRI. Whilst activation of ILC2s and the associated amplification of local type 2 immunity has been previously shown to reduce the deleterious consequences of AKI, our results r...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conditions:   Advanced Lung Disease;   COPD;   ILD Intervention:   Sponsor:   Klinikum Berchtesgadener Land der Schön-Kliniken Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions. The BLTx recipients with CF had inferior survival and longer ICU LOS when receiving organs from donors 55 years or older. Recipients with COPD, ILD, or in the “other” group did not have inferior survival in multivariate models.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Pentraxin-3 (PTX3) polymorphisms influence the risk of invasive pulmonary aspergillosis (IPA) in chronic obstructive pulmonary disease patients, hematopoietic stem cell recipients and solid organs recipients. Therefore, we aimed to investigate this association in a large lung transplant population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 266 Source Type: research
Single lung transplants (SLT) for chronic obstructive pulmonary disease (COPD) are characterized by hyperinflation of the contralateral native lung which may be more pronounced in single left lung transplants. Although single and double lung transplant (DLT) outcomes have been investigated, single right and left lung transplants have never been rigorously compared to evaluate disease specific differences.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 447 Source Type: research
Although COPD patients account for a large proportion of lung transplants, whether double lung transplantation (DLT) versus single (SLT) improves survival for COPD patients is not well established.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 540 Source Type: research
The objective of this survey was to assess the practices of international lung transplant (LTx) centers, pertaining to the testing for, and replacement of, AAT in patients with AATD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 816 Source Type: research
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