Cutaneous liver X receptor activation prevents the formation of imiquimod-induced psoriatic dermatitis

Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation (Nestle et al. 2009). In recent years, psoriasis is recognized as an immunometabolic disease associate with multiorgan abnormalities and dyslipidemia (Sterry et al. 2007); however, it remains unclear whether the dysregulation of lipid metabolism in the skin affects the pathogenesis of psoriasis. Liver X receptor (LXR) is a nuclear receptor composed of two isoforms, LXR α (Nr1h3) and LXRβ (Nr1h2) (Chawla et al.

Source: Journal of Investigative Dermatology - September 20, 2021 Category: Dermatology Authors: Masayuki Otsuka, Gyohei Egawa, Teruki Dainichi, Toshiaki Okuno, Yoshihiro Ishida, Zachary Chow, Ryota Asahina, Toshiya Miyake, Takashi Nomura, Akihiko Kitoh, Takehiko Yokomizo, Kenji Kabashima Tags: Letters to the Editor Source Type: research