Pathology of lung-specific thrombosis and inflammation in COVID-19

CONCLUSIONS: studying (ultra)structural features of the autopsy lung samples from patients with COVID-19 has provided evidence for a pathogenic link between inflammation and thrombosis. The major features in the lungs of COVID-19 patients comprised primary inflammatory thrombosis associated with diffuse alveolar damage. The lungs had pronounced circulatory changes with inflammation-dependent intravascular blood clotting, whereas heart, brain, and kidneys had predominantly degenerative changes that were distinct from the lung pathology.PMID:34538029 | DOI:10.1111/jth.15532

Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Rafael R Khismatullin Anastasia A Ponomareva Chandrasekaran Nagaswami Rozalina A Ivaeva Kathleen T Montone John W Weisel Rustem I Litvinov Source Type: research