Antioxidant and antiviral activity of fullerol against Zika virus

In this study, fullerol did not alter cell viability at the concentrations tested, proving to be inert, beyond to presenting high antioxidant power at low concentrations. ZIKV infection of human glioblastoma increased the production of reactive oxygen species by 60% and modulated the Nrf-2 pathway activity negatively. After treatment with fullerol, both conditions were restored to baseline levels. Additionally, fullerol was able to reduce viral production by up to 90%. Therefore, our results suggest that fullerol as a promising candidate in the control of ZIKV infections, presenting both antioxidant and antiviral action.PMID:34536367 | DOI:10.1016/j.actatropica.2021.106135

Source: Acta Tropica - September 18, 2021 Category: Infectious Diseases Authors: Samille Henriques Pereira Let ícia Trindade Almeida Ariane Coelho Ferraz Marina de Souza Ladeira Luiz Orlando Ladeira C íntia Lopes de Brito Magalhães Breno de Mello Silva Source Type: research