Pioglitazone mediates apoptosis in Caki cells via downregulating c-FLIP < sub > (L) < /sub > expression and reducing Bcl-2 protein stability

In conclusion, these findings indicated that pioglitazone-induced apoptosis is regulated through caspase-mediated degradation of FLIP(L) and reduction of Bcl-2 protein stability, suggesting that pioglitazone is a feasible apoptotic agent that could be used in the treatment of human RC.PMID:34466155 | PMC:PMC8387863 | DOI:10.3892/ol.2021.13004

Source: Oncology Letters - September 1, 2021 Category: Cancer & Oncology Authors: Ji Hoon Jang Tae-Jin Lee Eon-Gi Sung In-Hwan Song Joo-Young Kim Source Type: research