Epstein-Barr virus associated gastric dysplasia: a new rare entity?

We report an unusual case of an EBV-associated foveolar gastric dysplasia associated with a focus of EBV-positive low-grade tubular adenocarcinoma, arisen in the context of a lymphocytic-like (EBV-positive) gastritis. The present case offers the unique opportunity to determine whether EBV is an early or late event in gastric cancer development and to evaluate its prevalence in patients with gastric dysplasia. To properly address this question, we investigated EBER expression in a large mono-institutional series of gastric and gastro-esophageal cancers (n = 594) and associated precursor lesions (n = 84). All the selected gastric dysplastic lesions (n = 43) resulted EBV negative. In most cases, EBV is present only in gastric and gastroesophageal junction adenocarcinomas, but not in their precursor lesions. However, the reported case indicates that non-conventional EBV-associated dysplasia may represent a novel histopathological entity in the gastric dysplasia scenario and that EBV could play an early direct role in gastric carcinogenesis.
Source: Virchows Archiv - Category: Pathology Source Type: research

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Conclusion: CT was an effective, non-invasive method for diagnosis of duodenal lipoma. CT imaging could clearly discern location, size, shape, and nature of duodenal lipomas. Duodenal lipoma can be associated with digestive tract inflammatory diseases and tumors in different locations, and its diagnosis is potentially valuable for their prevention and treatment.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Background The involvement of gastrointestinal tract is rare in sarcoidosis. Endoscopic and histologic evaluation likely provides diagnostic clue in sarcoidosis patients. The aims were to assess the frequency of abnormal endoscopy and histology in patients with sarcoidosis undergoing endoscopic evaluation and to characterize the endoscopic and histologic features in sarcoidosis of the gastrointestinal tract. Methods This was a retrospective study that included 230 patients with a confirmed diagnosis of sarcoidosis in a tertiary care center. The endoscopic and pathology reports were assessed, and serum angiotensi...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
AbstractIn the West, the incidence of esophageal adenocarcinoma, which is a long-term complication of damage by gastroesophageal reflux, has been rising over recent decades. Two main factors are likely to account for this increase. The first is the rising incidence of central obesity which promotes gastroesophageal reflux. The second is the falling incidence ofH. pylori infection and associated atrophic gastritis which reduces the acidity and peptic activity of gastric juice, the main factors damaging to the esophageal mucosa. The rise in esophageal adenocarcinoma has been mirrored by a fall in gastric cancer consistent wi...
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
AbstractGastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors uniqueO-glycans carrying terminal α1,4-linkedN-acetylglucosamine residues ( αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic againstHelicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient inA4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase ( α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type ade...
Source: Histochemistry and Cell Biology - Category: Biomedical Science Source Type: research
Reduced αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer. Histochem Cell Biol. 2018 Apr 16;: Authors: Yamanoi K, Nakayama J Abstract Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. py...
Source: Acta Histochemica - Category: Biochemistry Authors: Tags: Histochem Cell Biol Source Type: research
Publication date: Available online 7 December 2017 Source:Pathology - Research and Practice Author(s): Rodolfo T.C. Takaoka, Nathália D. Sertório, Lara P.J. Magalini, Leandro M. Do Santos, Helena R. Souza, Melina M. Iyomasa-Pilon, Lucas Possebon, Sara S. Costa, Ana P. Girol The anti−inflammatory protein Annexin−A1 (ANXA1) is associated to tumor invasion process and its actions can be mediated by formylated peptides receptors (FPRs). Therefore, we evaluated the expression and correlation of ANXA1, FPR and cyclooxygenase−2 (COX−2) enzyme in esophageal and stomach inflammations and neopl...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ol AP Abstract The anti-inflammatory protein Annexin-A1 (ANXA1) is associated to tumor invasion process and its actions can be mediated by formylated peptides receptors (FPRs). Therefore, we evaluated the expression and correlation of ANXA1, FPR and cyclooxygenase-2 (COX-2) enzyme in esophageal and stomach inflammations and neoplasias. The study of proteins was performed by immunohistochemistry in biopsies of esophagitis, Barrett's esophagus, squamous cell carcinoma and adenocarcinoma of the esophagus, as well as gastritis, stomach polypus and gastric adenocarcinoma. The intensity of the expressions was evaluated ...
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
A Western study using serological tests for gastric mucosal atrophy and H. pylori status suggested two distinct etiologies of esophagogastric junction (EGJ) cancer i.e. H. pylori associated atrophic gastritis and non-atrophic gastric mucosa resembling esophageal adenocarcinoma (Gut 2007;56:918 –925). In this multicenter collaborative study, we investigated whether the same aspect (two distinct etiologies) exists in Japanese patients with superficial EGJ cancer.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday – ASGE poster Source Type: research
Esophagogastric junction (EGJ) adenocarcinoma has been on the increase in Western countries. However, in Asian countries, data on the incidence of EGJ adenocarcinoma are evidently lacking. In the present review, we focus on the current clinical situation of EGJ adenocarcinoma in three Asian countries: Japan, Hong Kong, and Malaysia. The incidence of EGJ adenocarcinoma has been reported to be gradually increasing in Malaysia and Japan, whereas it has stabilized in Hong Kong. However, the number of cases in these countries is comparatively low compared with Western countries. A reason for the reported difference in the incid...
Source: Digestive Endoscopy - Category: Gastroenterology Authors: Tags: Endoscopic diagnosis of EG junction cancer Source Type: research
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