Efficacy and safety of erenumab in Japanese migraine patients with prior preventive treatment failure or concomitant preventive treatment: subgroup analyses of a phase 3, randomized trial

ConclusionErenumab was associated with clinically relevant improvements in all efficacy endpoints and was well tolerated across all subgroups of Japanese migraine patients with/without prior preventive treatment failure(s) and with/without concomitant preventive treatment.Trial registrationClinicaltrials.gov. NCT03812224. Registered January 23, 2019.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research

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Self-administered external trigeminal nerve stimulation is superior to sham stimulation in relieving pain for patients with episodic migraine, results from a phase 3 study show.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Condition:   Cluster Headache, Episodic Intervention:   Procedure: PET-MRI in pain-free remission period Sponsor:   Hospices Civils de Lyon Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Lasmiditan with the 50 mg, 100 mg, and 200 mg doses are effective and safe in acute migraine treatment. Lasmiditan 200 mg is more effective than lasmiditan 100 mg in pain freedom, while lasmiditan 100 mg is better tolerated in the short-term follow-up. Further larger sample-size RCTs are required to verify the applicability and tolerability in the long term.PMID:34660796 | PMC:PMC8517628 | DOI:10.1155/2021/6663591
Source: Biomed Res - Category: Research Authors: Source Type: research
Pain is a major health problem among U.S. young adults. The passage of the Affordable Care Act's young adult mandate in 2010 allowed individuals to remain on their parents' health insurance until age 26. Although studies have documented the positive effects of this mandate on various health outcomes, less is known about its association with self-reported pain among young adults. Using the 2002 to 2018 National Health Interview Survey (N = 48,053) and a difference-in-differences approach, we compared the probabilities of reporting pain at 5 sites (low back, joint, neck, headache/migraine, and facial/jaw) and the number of p...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Orv Hetil. 2021 Oct 17;162(42):1671-1677. doi: 10.1556/650.2021.32332.ABSTRACTÖsszefoglaló. A COVID-19-fertőzésen átesett betegek közül többen elhúzódó panaszokról számolnak be a felépülést követően, sokaknál tartósan fennáll a köhögés, a nehézlégzés, a mellkasi fájdalom, a légszomj attól függetlenül, hogy enyhe vagy súlyosabb tüneteket okozott a koronavírus. A betegek erőtlennek érzik magukat, erős f&aacut...
Source: Orvosi Hetilap - Category: General Medicine Authors: Source Type: research
NEW BRUNSWICK, N.J., October 15, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced the U.S. Food and Drug Administration’s (FDA) Vaccines and Related Biological Products Advisory Committee (VRBPAC) unanimously voted 19-0 to recommend Emergency Use Authorization (EUA) for a booster dose of the Johnson &Johnson COVID-19 vaccine for adults aged 18 and older at least two months following initial vaccination with the single-shot vaccine. The vote was based on findings from two Company clinical trials, including the Phase 3 ENSEMBLE 2 study, which evaluated a booster dose of the Johnson &J...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Recognizing the positive association between painful TMD and PHs can help dentists and physicians treat the pain and avoid it, or recommend the patient to a specialist.PMID:34649707 | DOI:10.1016/j.adaj.2021.07.021
Source: Journal of the American Dental Association - Category: Dentistry Authors: Source Type: research
CONCLUSIONS: Most chiropractic users with diagnosed neck or back pain were considered discordant with treatment frequency guidelines, which may indicate inefficiencies in treatment and inefficient use of healthcare resources.PMID:34653025
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Source Type: research
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Recognizing the positive association between painful TMD and PHs can help dentists and physicians treat the pain and avoid it, or recommend the patient to a specialist.PMID:34649707 | DOI:10.1016/j.adaj.2021.07.021
Source: Journal of the American Dental Association - Category: Dentistry Authors: Source Type: research
CONCLUSIONS: Most chiropractic users with diagnosed neck or back pain were considered discordant with treatment frequency guidelines, which may indicate inefficiencies in treatment and inefficient use of healthcare resources.PMID:34653025
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Source Type: research
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