Beneficial effects of dietary polyphenols in the prevention and treatment of NAFLD: cell-signaling pathways underlying health effects

CONCLUSION: Polyphenols are relevant bioactive compounds in terms of prevention and treatment of NAFLD, which exhibit low bioavailability and instability in biological systems that could limit their health effects. These drawbacks reinforce the necessity of further studies to improve the efficacy of polyphenol formulations for human interventions.PMID:34525916 | DOI:10.2174/0929867328666210825111350
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research

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Contributors : Xuezhu Li ; Dipankar Bhattacharya ; Scott L Friedman ; John C HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) that underlies a growing prevalence of cirrhosis and liver cancer worldwide. Clinical studies suggest that NASH is an independent risk factor for chronic kidney disease (CKD), but models and mechanisms linking these two diseases are lacking. Here, we have characterized the renal function, histological features, and transcriptomic profile in a well-validated murin...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
World J Hepatol. 2021 Jun 27;13(6):620-633. doi: 10.4254/wjh.v13.i6.620.ABSTRACTOne of the most commonly known genes involved in chronic diffuse liver diseases pathogenesis are genes that encodes the synthesis of glutathione-S-transferase (GST), known as the second phase enzyme detoxification system that protects against endogenous oxidative stress and exogenous toxins, through catalisation of glutathione sulfuric groups conjugation and decontamination of lipid and deoxyribonucleic acid oxidation products. The group of GST enzymes consists of cytosolic, mitochondrial and microsomal fractions. Recently, eight classes of sol...
Source: World Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
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