Cancers, Vol. 13, Pages 4696: Prostate Cancer —Focus on Cholesterol
Cancers, Vol. 13, Pages 4696: Prostate Cancer—Focus on Cholesterol
Cancers doi: 10.3390/cancers13184696
Authors:
Lucija Škara
Ana Huđek Turković
Ivan Pezelj
Alen Vrtarić
Nino Sinčić
Božo Krušlin
Monika Ulamec
Prostate cancer (PC) is the most common malignancy in men. Common characteristic involved in PC pathogenesis are disturbed lipid metabolism and abnormal cholesterol accumulation. Cholesterol can be further utilized for membrane or hormone synthesis while cholesterol biosynthesis intermediates are important for oncogene membrane anchoring, nucleotide synthesis and mitochondrial electron transport. Since cholesterol and its biosynthesis intermediates influence numerous cellular processes, in this review we have described cholesterol homeostasis in a normal cell. Additionally, we have illustrated how commonly deregulated signaling pathways in PC (PI3K/AKT/MTOR, MAPK, AR and p53) are linked with cholesterol homeostasis regulation.
Source: Cancers - Category: Cancer & Oncology Authors: Lucija Škara Ana Hu đek Turković Ivan Pezelj Alen Vrtari ć Nino Sin čić Bo žo Krušlin Monika Ulamec Tags: Review Source Type: research