Autoimmune & inflammatory nmd

Anti-transcription intermediary factor 1 γ (TIF1γ) antibodies are one of the myositis-specific antibodies frequently detected in dermatomyositis (DM). To elucidate the characteristics of anti-TIF1γ antibody-positive myositis, we extracted cases with anti-TIF1γ antibodies from idiopathic inflammatory myopathy (IIM) patients who underwen t muscle biopsy from 2008 to 2019, and analyzed the clinicopathological findings. We found 87 cases of IIM (40 DM, 3 polymyositis, 25 immune-mediated necrotizing myopathy, 14 antisynthetase syndrome, and 5 nonspecific myositis), among which anti-TIF1γ antibodies were positive in 13 cases, and all o f them were DM.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research