Autoimmune & inflammatory nmd

Inclusion body myositis (IBM) belongs to the family of dysimmune inflammatory myopathies (DIMs). It is characterized by T-cells infiltrates and abnormal expression of major histocompatibility complex (MHC)-II by myofibers. Notably, MHC-II expression is induced in response to IFN γ binding and T-cells are major producers of IFNγ. Our aim was to dissect the pathogenic role of IFNγ in IBM. First, we showed that IFNγ signaling was upregulated in IBM patients’ muscles compared with muscles from DIMs patients and healthy controls.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research