Pompe disease

The efficacy of avalglucosidase alfa compared to alglucosidase alfa as measured by the EuroQol 5-dimension 5-level (EQ-5D-5L) from the phase 3 COMET trial in late-onset Pompe disease (LOPD) is presented. EQ-5D-5L, a multi-attribute utility measure of health-related quality of life, was collected in treatment-na ïve LOPD patients. Change from baseline to week 49 in the five dimensions of EQ-5D-5L, including mobility, usual activities, self-care, pain/discomfort and anxiety/depression; the derived patient's health state/index (range: 0 to 1); and the visual analogue scale (VAS, self-rated health on a 0 [wor st health] to 100 [best health]) were compared for the two treatment groups using Wilcoxon-Mann-Whitney test at the nominal level.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research

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ConclusionsThis study shows the effectiveness of a blended Internet-based MBI in increasing HRQoL and optimism in patients with IBD. It also highlights the use of MBIs to treat psychological impairment in IBD.Trial Registration.NCT 02,963,246, 15/11/2016.
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
Neuropsychiatric symptoms (NPS) such as agitation/aggression, depression, and anxiety are common and challenging experiences for those with dementia and their caregivers (1). It has been hypothesized that a driving factor in NPS is presence of unmet needs for persons with dementia, as cognitive impairment (CI) disrupts ability of persons with dementia not only to provide for their needs but also to communicate needs to others (1). There is a mismatch between personality habits, physical/mental state (e.g., pain, anxiety), and environmental factors (e.g., social isolation and sensory deprivation), which then drives NPS as a...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Brief Report Source Type: research
ConclusionsThis study shows the effectiveness of a blended Internet-based MBI in increasing HRQoL and optimism in patients with IBD. It also highlights the use of MBIs to treat psychological impairment in IBD.Trial Registration.NCT 02,963,246, 15/11/2016.
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
ConclusionMT can alleviate various types of adverse reactions by effectively relieving patients ’ somatic symptoms and improving their psychological states and overall functions. It can be popularized as a significant non-drug therapy. At present, however, the clinical application of MT is neither extensive nor having sufficient basic research. Consequently, we should attach importance to th is application.
Source: Journal of Acupuncture and Tuina Science - Category: Complementary Medicine Source Type: research
In the wake of multiple legal challenges, the Biden Administration late last month aimed to fortify the Deferred Action for Childhood Arrivals (DACA) program with a new rule that would shield more than 600,000 undocumented people brought to the U.S. by their parents. While proponents of the program welcomed the move and heralded it an “effort to bulletproof the DACA program,” our response in this moment overlooks a fundamental problem: each challenge on immigration—whether the Muslim Ban, family separation, or challenging DACA—takes a toll on refugee and migrants through vicarious trauma and weather...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
This study investigated the limitations and restrictions in the most relevant brief ICF core set categories for chronic low back pain (cLBP) as automatically predicted from routinely measured outcomes using a novel, validated mapping algorithm. Materials and Methods: Of 2718 cLBP patients recruited, data from 1541 (64% females) were available from before and at the end of 6 months comprehensive outpatient rehabilitation. Assessments included the Roland Morris Disability Questionnaire (RMDQ) and Pain Disability Index (PDI) questionnaires, the percentage of patients with predicted limitations and restrictions in impor...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
J Palliat Care. 2021 Oct 21:8258597211045780. doi: 10.1177/08258597211045780. Online ahead of print.ABSTRACTHospitalization is a stressful experience both for primary caregivers (PCs) and cancer patients alike. Although there is significant evidence that PCs of cancer patients can experience significant caregiver burden (CB), less is known about the relationships between PCs and patient symptom severity that influence CB. Methods: In this cross-sectional study, measures of the symptom severity were obtained from cancer patients. The PCs were assessed for CB. Associations between patients' symptoms and demographic character...
Source: Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
CONCLUSION: Moderate to low resilience scores and moderate to high levels of illness threatening can be seen in the acute phase of TTS, reflecting the severity of the experience as an adverse life event. Patients suffering from TTS present in the acute phase with a high prevalence of somatic disorders and relatively high prevalence of depressive disorders.PMID:34671830 | DOI:10.1007/s00508-021-01957-1
Source: Wiener Klinische Wochenschrift - Category: General Medicine Authors: Source Type: research
J Palliat Care. 2021 Oct 21:8258597211045780. doi: 10.1177/08258597211045780. Online ahead of print.ABSTRACTHospitalization is a stressful experience both for primary caregivers (PCs) and cancer patients alike. Although there is significant evidence that PCs of cancer patients can experience significant caregiver burden (CB), less is known about the relationships between PCs and patient symptom severity that influence CB. Methods: In this cross-sectional study, measures of the symptom severity were obtained from cancer patients. The PCs were assessed for CB. Associations between patients' symptoms and demographic character...
Source: Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Clin Neuropsychol. 2021 Oct 20:1-22. doi: 10.1080/13854046.2021.1991481. Online ahead of print.ABSTRACTOBJECTIVE: Examine associations between subjective memory complaints (SMCs), concussion history, and cognitive, psychological, and physical health in older men from the general population.METHOD: Participants were 504 men aged 50-79 who were recruited using an online labor market. Participants completed a survey assessing demographics, medication history, concussion history, recent memory problems, and additional aspects of recent cognitive, mental, and physical health.RESULTS: Men with a lifetime history of ≥3 concuss...
Source: The Clinical Neuropsychologist - Category: Psychiatry & Psychology Authors: Source Type: research
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