Myotonic dystrophy

This study aims to identify the predictors of dysphagia and aspiration in a cohort of people living with DM1 over a range of disease severity and stages.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research

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AbstractA 62-year-old woman who has a history of chronic hepatitis B and hypertension, presented to a local hospital with cough and fever and was admitted on day 3. Since her chest CT revealed bilateral ground-glass opacities, and SARS-Cov-2 saliva PCR was positive, she was diagnosed with COVID-19 pneumonia and was treated with favipiravir. On day 7, she was in a relatively good condition, as she was afebrile with a little cough. However, on day 18, she became coma which was followed with convulsive seizures, prompting administration of diazepam and levetiracetam. Afterwards, she was then transferred to our hospital, prese...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: CASE REPORT Source Type: research
In clinical practice, we commonly face adversity when encountering dysfunction of the cough reflex. Similar to ancient Roman deity Janus, it often presents with one of two opposing “faces”. Continual aberrant activation of the cough reflex, also known as chronic cough, can cause great detriment to quality of life and many of these patients are left misdiagnosed and undertreated. In contrast, loss of normal functioning of the cough reflex is the cause of a significant proportion of mortality in the elderly, primarily through the development of aspiration pneumonia. In this review we discuss both hyper- and hypo-...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that more than 30 company-sponsored studies, including six oral presentations, will be featured during the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8. Janssen presentations will include new data and updates for both approved and investigational therapeutics that are being studied for the treatment of various solid tumors and blood cancers. Immediately following ASCO, additional data will be featured during the European Hematology Association (EHA) Virtual Congress, June 9-17. A c...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
J Family Med Prim Care. 2021 Jan;10(1):558-560. doi: 10.4103/jfmpc.jfmpc_1627_20. Epub 2021 Jan 30.ABSTRACTA 17-year-old girl with hypoxic encephalopathy was hospitalized over four times in a year because of recurrent aspiration pneumonia (AP). She had dysphagia and reduced cough reflex as sequelae of brain damage. To prevent aspiration, a gastric tube was placed for feeding, but it did not reduce the frequency of AP because the gastroesophageal reflux caused backflow. However, after the Kampo medicine bukuryoingohangekobokuto (BRIHK) was added to the prescriptions, her sputum and gastroesophageal reflux was remarkably red...
Source: Primary Care - Category: Primary Care Authors: Source Type: research
This study aimed to determine whether factors, including oral status, swallowing function, and oral intake level, were related to survival outcomes in older patients hospitalized for AP. The study enrolled patients with AP who were admitted to our hospital between February 2017 and November 2019. Patients were divided into two groups based on the 90-day mortality after the first swallowing function evaluation: survivors and deceased. The data were compared between the two groups. A total of 29 patients were diagnosed with AP. Of these patients, 13 died within 90  days. The numbers of patients who could not use removab...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
AbstractProgressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by a high prevalence of dysphagia, cough dysfunction, and resultant aspiration pneumonia. Sensorimotor cough function is important for airway clearance in people with dysphagia. Upregulation of cough has been demonstrated in healthy adults and Parkinson ’s disease; however, the feasibility of cough rehabilitation in PSP is unknown. We sought to assess feasibility by examining the immediate effects of a novel sensorimotor training in airway protection (smTAP) on upregulation of cough function in PSP. Fifteen individuals with PSP ...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
AbstractEarly detection of dysphagia and specifically aspiration is essential to prevent and reduce complications of hospitalized patients in rehabilitation centers. Bedside screening test are often used to evaluate swallowing disorders, but their results may be questionable due to insufficient and inconsistent sensitivity and specificity. To compare the sensitivity and specificity of various bedside screening tests for detecting aspiration in hospitalized rehabilitation patients. A prospective observational study was performed in 150 consecutive patients of a tertiary rehabilitation hospital. Patients were evaluated regar...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
CONCLUSIONS &IMPLICATIONS: This survey gives valuable insight into the current practice and perceptions of SLTs in the UK working in acute stroke settings in relation to CRT. It highlights discrepancies between reported approaches and recommendations from existing guidelines and validation studies. The variation in responses indicates a need to develop a consensus statement and further research to guide practice. What this study adds What is already known on the subject CRT is gaining popularity as a screening tool for the clinical identification of SA with acute stroke patients. However, there is a lack of consensus i...
Source: International Journal of Language and Communication Disorders - Category: Speech-Language Pathology Authors: Tags: Int J Lang Commun Disord Source Type: research
Authors: Wada S, Nagasaki Y, Arimizu Y, Shimo M, Matsukuma Y, Okamoto M, Yoshida S, Ohashi I, Hashimoto G, Kuwashiro T, Yasaka M, Okada Y Abstract A 69-year-old man was admitted to our hospital under diagnosis of pneumonia due to SARS-CoV-2 (Day 0). He underwent endotracheal intubation from Day 3. Although his respiratory condition improved and anesthetic drugs were discontinued, no cough reflex was observed despite intubation having been performed until Day 17. His tendon reflexes were also diminished. We suspected that he had developed Guillain-Barré syndrome (GBS), and administered intravenous immunoglobu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractAspiration pneumonia is a leading cause of death in Parkinson ’s disease (PD), occurring as a result of impaired cough and swallowing function. However, portable diagnostic tools for cough assessment and dysphagia screening are limited. Therefore, the aims of this study were to determine if: (1) ‘Handheld Cough Testing’ (HCT), a novel tool developed for cough assessments, could detect differences in cough airflow and sensation during reflex and voluntary cough tasks; and (2) HCT could screen for dysphagia in PD with high sensitivity. Twenty-two people with PD underwent HCT and swallowing assessmen...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
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