Staphylococcus aureus infections in children

Purpose of review Staphylococcus aureus is the most common invasive bacterial pathogen infecting children in the U.S. and many parts of the world. This major human pathogen continues to evolve, and recognition of recent trends in epidemiology, therapeutics and future horizons is of high importance. Recent findings Over the past decade, a relative rise of methicillin-susceptible S. aureus (MSSA) has occurred, such that methicillin-resistant S. aureus (MRSA) no longer dominates the landscape of invasive disease. Antimicrobial resistance continues to develop, however, and novel therapeutics or preventive modalities are urgently needed. Unfortunately, several recent vaccine attempts proved unsuccessful in humans. Summary Recent scientific breakthroughs highlight the opportunity for novel interventions against S. aureus by interfering with virulence rather than by traditional antimicrobial mechanisms. A S. aureus vaccine remains elusive; the reasons for this are multifactorial, and lessons learned from prior unsuccessful attempts may create a path toward an effective preventive. Finally, new diagnostic modalities have the potential to greatly enhance clinical care for invasive S. aureus disease in children.
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: PAEDIATRIC AND NEONATAL INFECTIONS: Edited by Scott H. James and David W. Kimberlin Source Type: research

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CONCLUSIONS: ST59, ST8, and ST45 MRSA are the leading three MRSA strains causing SSTIs in Taiwan, 2017, but the molecular distribution varied distinctly between the custodial facilities and hospital settings. The genotypical mupirocin resistance rate is quite high in this study. The frequency of chlorhexidine resistance gene is relatively low, especially in MRSA isolates from custodial facilities.PMID:34635424 | DOI:10.1016/j.jmii.2021.08.013
Source: Journal of Microbiology, Immunology, and Infection - Category: Microbiology Authors: Source Type: research
Conclusion: CaD23 is a novel alpha-helical, membrane-active synthetic HDP that can enhance and expedite the antimicrobial action of antibiotics against Gram-positive bacteria when used in combination. MD simulations serves as a powerful tool in revealing the peptide secondary structure, dissecting the mechanism of action, and guiding the design and optimisation of HDPs.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: The study revealed an alarming rate of resistance to the commonly used antimicrobial agents used in treating HAIs. Also the relationship between AMR and some risk factors and thus taking steps towards controlling them have been shown.PMID:34540152 | PMC:PMC8408023 | DOI:10.18502/ijm.v13i2.5978
Source: Iranian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Exp Eye Res. 2021 Sep 8:108764. doi: 10.1016/j.exer.2021.108764. Online ahead of print.ABSTRACTVirulence-factor encoding genes (VFGs) and antimicrobial resistance genes (ARGs) of ocular Methicillin-Resistant Staphylococcus aureus (MRSA), are the reason behind the common cause of severe and untreatable ocular infection and are largely unknown. The unavailability of the complete genome sequence of ocular MRSA strains hinders the unambiguous determination of ARGs and VRGs role in disease pathogenesis and their genomic location. To fulfill this critical need, we achieved the high-quality complete genome of four ocular MRSA str...
Source: Experimental Eye Research - Category: Opthalmology Authors: Source Type: research
Arch Microbiol. 2021 Sep 6. doi: 10.1007/s00203-021-02564-4. Online ahead of print.ABSTRACTInfections due to methicillin-resistant Staphylococcus aureus (MRSA) are a growing concern for public health resulting in increase in morbidity, length of hospital stay, and cost of treatment. MRSA nasal swab screening may give clinicians additional information for decision of empiric antimicrobial agents. While increasing antibiotic resistance leads to new treatment approaches, bacteriophages are one of the most promising methods for these alternatives. It was aimed to determine the effectiveness of bacteriophages against MRSA isola...
Source: Archives of Microbiology - Category: Microbiology Authors: Source Type: research
Int J Biol Macromol. 2021 Sep 1;190:33-43. doi: 10.1016/j.ijbiomac.2021.08.199. Online ahead of print.ABSTRACTStaphylococcus aureus is a common cause of skin infections, food poisoning and severe life-threatening infections. Methicillin-Resistant Staphylococcus aureus (MRSA) is known to cause chronic nosocomial infections by virtue of its multidrug resistance and biofilm formation mechanisms. The antimicrobial resistance owned by S. aureus is primarily due to efflux pumps and formation of microbial biofilms. These drug resistant, sessile and densely packed microbial communities possess various mechanisms including quorum s...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
CONCLUSION: Altogether, the peptide discovered from rhizosphere metagenome hold potential in inhibiting the growth of both the gram positive and gram negative bacteria, and was equally effective in inhibiting the multidrug resistant pathogenic strains (MRSA).PMID:34477502 | DOI:10.2174/0929866528666210903162137
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research
Rev Peru Med Exp Salud Publica. 2021 Apr-Jun;38(2):313-317. doi: 10.17843/rpmesp.2021.382.6867. Epub 2021 Aug 30.ABSTRACTIn order to determine the frequency of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates and to describe the antimicrobial resistance pattern and genotype, a cross-sectional study was conducted in 2017 at the Hospital Nacional Cayetano Heredia in Lima, Peru. We found a MRSA prevalence of 46.1% in the 115 analyzed S. aureus isolates; most were reported from different secretions (26.4%) and blood (18.9%). We found high co-resistance (>75%) to clindamycin, erythromycin, ge...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Authors: Source Type: research
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